Bifurcation analyses in the cyanobacterial circadian clock model

Gen Kurosawa; Kazuyuki Aihara; Yoh Iwasa

doi:10.1109/LSSA.2006.250394

Bifurcation analyses in the cyanobacterial circadian clock model

Gen Kurosawa, Kazuyuki Aihara, Yoh Iwasa

dynamic biology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A conspicuous property of the circadian clock in cyanobacteria is that endogenous rhythm continues when protein abundances are kept constant either in the presence of translation and transcription inhibitors. Here we extend the study of a model recently proposed for the cyanobaterial circadian clock (Biophysical Journal in press). We theoretically show that balanced ratio among KaiA, KaiB, and KaiC proteins is required for the generation of oscillations by using our model recently proposed [1]. Bifurcation analyses show that cooperativity for the mutual inhibitoiy process in the model does not always enhance the generation of oscillations though cooperativity for the inhibition of transcription and in the nuclear transport of clock proteins in Goodwin type models extensively studied is known to always enhance the generation of oscillations.

Original language	English
Title of host publication	2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006
DOIs	https://doi.org/10.1109/LSSA.2006.250394
Publication status	Published - Dec 1 2006
Event	2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006 - Bethesda, MD, United States Duration: Jul 13 2006 → Jul 14 2006

Other

Other	2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006
Country	United States
City	Bethesda, MD
Period	7/13/06 → 7/14/06

All Science Journal Classification (ASJC) codes

Health(social science)
Assessment and Diagnosis
Medicine(all)
Health Information Management
Electrical and Electronic Engineering
Human-Computer Interaction
Computer Science Applications
Signal Processing

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title = "Bifurcation analyses in the cyanobacterial circadian clock model",

abstract = "A conspicuous property of the circadian clock in cyanobacteria is that endogenous rhythm continues when protein abundances are kept constant either in the presence of translation and transcription inhibitors. Here we extend the study of a model recently proposed for the cyanobaterial circadian clock (Biophysical Journal in press). We theoretically show that balanced ratio among KaiA, KaiB, and KaiC proteins is required for the generation of oscillations by using our model recently proposed [1]. Bifurcation analyses show that cooperativity for the mutual inhibitoiy process in the model does not always enhance the generation of oscillations though cooperativity for the inhibition of transcription and in the nuclear transport of clock proteins in Goodwin type models extensively studied is known to always enhance the generation of oscillations.",

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