Abstract
A conspicuous property of the circadian clock in cyanobacteria is that endogenous rhythm continues when protein abundances are kept constant either in the presence of translation and transcription inhibitors. Here we extend the study of a model recently proposed for the cyanobaterial circadian clock (Biophysical Journal in press). We theoretically show that balanced ratio among KaiA, KaiB, and KaiC proteins is required for the generation of oscillations by using our model recently proposed [1]. Bifurcation analyses show that cooperativity for the mutual inhibitoiy process in the model does not always enhance the generation of oscillations though cooperativity for the inhibition of transcription and in the nuclear transport of clock proteins in Goodwin type models extensively studied is known to always enhance the generation of oscillations.
Original language | English |
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Title of host publication | 2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006 |
DOIs | |
Publication status | Published - Dec 1 2006 |
Event | 2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006 - Bethesda, MD, United States Duration: Jul 13 2006 → Jul 14 2006 |
Other
Other | 2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006 |
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Country | United States |
City | Bethesda, MD |
Period | 7/13/06 → 7/14/06 |
All Science Journal Classification (ASJC) codes
- Health(social science)
- Assessment and Diagnosis
- Medicine(all)
- Health Information Management
- Electrical and Electronic Engineering
- Human-Computer Interaction
- Computer Science Applications
- Signal Processing