Bifurcation analyses in the cyanobacterial circadian clock model

Gen Kurosawa, Kazuyuki Aihara, Yoh Iwasa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A conspicuous property of the circadian clock in cyanobacteria is that endogenous rhythm continues when protein abundances are kept constant either in the presence of translation and transcription inhibitors. Here we extend the study of a model recently proposed for the cyanobaterial circadian clock (Biophysical Journal in press). We theoretically show that balanced ratio among KaiA, KaiB, and KaiC proteins is required for the generation of oscillations by using our model recently proposed [1]. Bifurcation analyses show that cooperativity for the mutual inhibitoiy process in the model does not always enhance the generation of oscillations though cooperativity for the inhibition of transcription and in the nuclear transport of clock proteins in Goodwin type models extensively studied is known to always enhance the generation of oscillations.

Original languageEnglish
Title of host publication2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006
DOIs
Publication statusPublished - Dec 1 2006
Event2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006 - Bethesda, MD, United States
Duration: Jul 13 2006Jul 14 2006

Other

Other2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006
CountryUnited States
CityBethesda, MD
Period7/13/067/14/06

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All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Assessment and Diagnosis
  • Medicine(all)
  • Health Information Management
  • Electrical and Electronic Engineering
  • Human-Computer Interaction
  • Computer Science Applications
  • Signal Processing

Cite this

Kurosawa, G., Aihara, K., & Iwasa, Y. (2006). Bifurcation analyses in the cyanobacterial circadian clock model. In 2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006 [4015795] https://doi.org/10.1109/LSSA.2006.250394