Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement

Ayako Fujiwara, Masahiko Higashiyama, Takashi Kanou, Toshiteru Tokunaga, Jiro Okami, Ken Kodama, Kazumi Nishino, Yasuhiko Tomita, Isamu Okamoto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The discovery of a distinct subtype of non-small cell lung cancer (NSCLC) positive for rearrangement of the anaplastic lymphoma kinase gene (ALK) has had a substantial impact on personalized therapy for this disease. The clinical features associated with metastasis in individuals with ALK rearrangement-positive NSCLC remain to be fully characterized, however. We now describe a case of ovarian metastasis from NSCLC with ALK rearrangement. A 39-year-old woman underwent a right middle lobectomy for acinar-type adenocarcinoma of the lung (pT2aN2M0, stage IIIA). Fluorescence in situ hybridization (FISH) analysis of the resected tumor tissue revealed the presence of an ALK rearrangement. Twenty months later, a large intrapelvic mass was detected in the patient at follow-up. She underwent both left salpingo-oophorectomy and right ovarian cystectomy. Histological examination of the ovarian tumors showed acinar adenocarcinoma, and FISH analysis revealed the presence of ALK rearrangement, confirming a diagnosis of ALK rearrangement-positive NSCLC with ovarian metastasis. Although the ovary is an uncommon site for metastasis from lung cancer, physicians should be aware of the possibility for such metastasis during follow-up for female patients with ALK rearrangement-positive NSCLC. Further investigation is warranted to clarify the incidence of ovarian metastasis in NSCLC patients with ALK rearrangement.

Original languageEnglish
Pages (from-to)302-304
Number of pages3
JournalLung Cancer
Volume83
Issue number2
DOIs
Publication statusPublished - Feb 1 2014

Fingerprint

Gene Rearrangement
Non-Small Cell Lung Carcinoma
Neoplasm Metastasis
Fluorescence In Situ Hybridization
anaplastic lymphoma kinase
Cystectomy
Ovariectomy
Ovary
Lung Neoplasms
Neoplasms
Physicians
Incidence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

Fujiwara, A., Higashiyama, M., Kanou, T., Tokunaga, T., Okami, J., Kodama, K., ... Okamoto, I. (2014). Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement. Lung Cancer, 83(2), 302-304. https://doi.org/10.1016/j.lungcan.2013.11.022

Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement. / Fujiwara, Ayako; Higashiyama, Masahiko; Kanou, Takashi; Tokunaga, Toshiteru; Okami, Jiro; Kodama, Ken; Nishino, Kazumi; Tomita, Yasuhiko; Okamoto, Isamu.

In: Lung Cancer, Vol. 83, No. 2, 01.02.2014, p. 302-304.

Research output: Contribution to journalArticle

Fujiwara, A, Higashiyama, M, Kanou, T, Tokunaga, T, Okami, J, Kodama, K, Nishino, K, Tomita, Y & Okamoto, I 2014, 'Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement', Lung Cancer, vol. 83, no. 2, pp. 302-304. https://doi.org/10.1016/j.lungcan.2013.11.022
Fujiwara A, Higashiyama M, Kanou T, Tokunaga T, Okami J, Kodama K et al. Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement. Lung Cancer. 2014 Feb 1;83(2):302-304. https://doi.org/10.1016/j.lungcan.2013.11.022
Fujiwara, Ayako ; Higashiyama, Masahiko ; Kanou, Takashi ; Tokunaga, Toshiteru ; Okami, Jiro ; Kodama, Ken ; Nishino, Kazumi ; Tomita, Yasuhiko ; Okamoto, Isamu. / Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement. In: Lung Cancer. 2014 ; Vol. 83, No. 2. pp. 302-304.
@article{9486b75c85e946bfadcc686bd305e579,
title = "Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement",
abstract = "The discovery of a distinct subtype of non-small cell lung cancer (NSCLC) positive for rearrangement of the anaplastic lymphoma kinase gene (ALK) has had a substantial impact on personalized therapy for this disease. The clinical features associated with metastasis in individuals with ALK rearrangement-positive NSCLC remain to be fully characterized, however. We now describe a case of ovarian metastasis from NSCLC with ALK rearrangement. A 39-year-old woman underwent a right middle lobectomy for acinar-type adenocarcinoma of the lung (pT2aN2M0, stage IIIA). Fluorescence in situ hybridization (FISH) analysis of the resected tumor tissue revealed the presence of an ALK rearrangement. Twenty months later, a large intrapelvic mass was detected in the patient at follow-up. She underwent both left salpingo-oophorectomy and right ovarian cystectomy. Histological examination of the ovarian tumors showed acinar adenocarcinoma, and FISH analysis revealed the presence of ALK rearrangement, confirming a diagnosis of ALK rearrangement-positive NSCLC with ovarian metastasis. Although the ovary is an uncommon site for metastasis from lung cancer, physicians should be aware of the possibility for such metastasis during follow-up for female patients with ALK rearrangement-positive NSCLC. Further investigation is warranted to clarify the incidence of ovarian metastasis in NSCLC patients with ALK rearrangement.",
author = "Ayako Fujiwara and Masahiko Higashiyama and Takashi Kanou and Toshiteru Tokunaga and Jiro Okami and Ken Kodama and Kazumi Nishino and Yasuhiko Tomita and Isamu Okamoto",
year = "2014",
month = "2",
day = "1",
doi = "10.1016/j.lungcan.2013.11.022",
language = "English",
volume = "83",
pages = "302--304",
journal = "Lung Cancer",
issn = "0169-5002",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement

AU - Fujiwara, Ayako

AU - Higashiyama, Masahiko

AU - Kanou, Takashi

AU - Tokunaga, Toshiteru

AU - Okami, Jiro

AU - Kodama, Ken

AU - Nishino, Kazumi

AU - Tomita, Yasuhiko

AU - Okamoto, Isamu

PY - 2014/2/1

Y1 - 2014/2/1

N2 - The discovery of a distinct subtype of non-small cell lung cancer (NSCLC) positive for rearrangement of the anaplastic lymphoma kinase gene (ALK) has had a substantial impact on personalized therapy for this disease. The clinical features associated with metastasis in individuals with ALK rearrangement-positive NSCLC remain to be fully characterized, however. We now describe a case of ovarian metastasis from NSCLC with ALK rearrangement. A 39-year-old woman underwent a right middle lobectomy for acinar-type adenocarcinoma of the lung (pT2aN2M0, stage IIIA). Fluorescence in situ hybridization (FISH) analysis of the resected tumor tissue revealed the presence of an ALK rearrangement. Twenty months later, a large intrapelvic mass was detected in the patient at follow-up. She underwent both left salpingo-oophorectomy and right ovarian cystectomy. Histological examination of the ovarian tumors showed acinar adenocarcinoma, and FISH analysis revealed the presence of ALK rearrangement, confirming a diagnosis of ALK rearrangement-positive NSCLC with ovarian metastasis. Although the ovary is an uncommon site for metastasis from lung cancer, physicians should be aware of the possibility for such metastasis during follow-up for female patients with ALK rearrangement-positive NSCLC. Further investigation is warranted to clarify the incidence of ovarian metastasis in NSCLC patients with ALK rearrangement.

AB - The discovery of a distinct subtype of non-small cell lung cancer (NSCLC) positive for rearrangement of the anaplastic lymphoma kinase gene (ALK) has had a substantial impact on personalized therapy for this disease. The clinical features associated with metastasis in individuals with ALK rearrangement-positive NSCLC remain to be fully characterized, however. We now describe a case of ovarian metastasis from NSCLC with ALK rearrangement. A 39-year-old woman underwent a right middle lobectomy for acinar-type adenocarcinoma of the lung (pT2aN2M0, stage IIIA). Fluorescence in situ hybridization (FISH) analysis of the resected tumor tissue revealed the presence of an ALK rearrangement. Twenty months later, a large intrapelvic mass was detected in the patient at follow-up. She underwent both left salpingo-oophorectomy and right ovarian cystectomy. Histological examination of the ovarian tumors showed acinar adenocarcinoma, and FISH analysis revealed the presence of ALK rearrangement, confirming a diagnosis of ALK rearrangement-positive NSCLC with ovarian metastasis. Although the ovary is an uncommon site for metastasis from lung cancer, physicians should be aware of the possibility for such metastasis during follow-up for female patients with ALK rearrangement-positive NSCLC. Further investigation is warranted to clarify the incidence of ovarian metastasis in NSCLC patients with ALK rearrangement.

UR - http://www.scopus.com/inward/record.url?scp=84892882601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892882601&partnerID=8YFLogxK

U2 - 10.1016/j.lungcan.2013.11.022

DO - 10.1016/j.lungcan.2013.11.022

M3 - Article

C2 - 24360322

AN - SCOPUS:84892882601

VL - 83

SP - 302

EP - 304

JO - Lung Cancer

JF - Lung Cancer

SN - 0169-5002

IS - 2

ER -