Biliary neoplasia with extensive intraductal spread associated with liver cirrhosis: a hitherto unreported variant of biliary intraepithelial neoplasia

Shinichi Aishima, Yunosuke Nishihara, Eiji Tsujita, Kenichi Taguchi, Yuji Soejima, Akinobu Taketomi, Yasuharu Ikeda, Yoshihiko Maehara, Masazumi Tsuneyoshi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We describe the histopathologic features of 2 cases of biliary neoplasia with extensive intraductal spread arising in liver cirrhosis. The prevalence of this type of biliary neoplasia may be 0.4% from the review of 468 cases of cirrhotic liver. Histologic analysis revealed that the micropapillary proliferation of the atypical biliary epithelium composed of columnar cells with enlarged nuclei diffusely extended superficially from the septal intrahepatic bile duct to the reactive ductules associated with liver cirrhosis. Both cases exhibited prominent fibrous or sclerotic stroma near the biliary lesion. Immunohistochemical analysis revealed a characteristic cytokeratin and mucin expression pattern (CK7++, CK19++, CK20+, MUC1+/-, MUC2-, MUC5AC+, MUC6-). The tumor cytoplasm was focally positive for laminin γ2 together with linear staining of the basement membrane. Proliferative activity confirmed by Ki67 staining was relatively high. Both patients were disease-free for 3 years after the operation. We believe that the possibility of biliary neoplasia with extensive intraductal spread should be considered to be a variant of biliary intraepithelial neoplasia.

Original languageEnglish
Pages (from-to)939-947
Number of pages9
JournalHuman Pathology
Volume39
Issue number6
DOIs
Publication statusPublished - Jun 1 2008

Fingerprint

Liver Cirrhosis
Neoplasms
Staining and Labeling
Intrahepatic Bile Ducts
Laminin
Mucins
Keratins
Basement Membrane
Cytoplasm
Epithelium
Liver

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Biliary neoplasia with extensive intraductal spread associated with liver cirrhosis : a hitherto unreported variant of biliary intraepithelial neoplasia. / Aishima, Shinichi; Nishihara, Yunosuke; Tsujita, Eiji; Taguchi, Kenichi; Soejima, Yuji; Taketomi, Akinobu; Ikeda, Yasuharu; Maehara, Yoshihiko; Tsuneyoshi, Masazumi.

In: Human Pathology, Vol. 39, No. 6, 01.06.2008, p. 939-947.

Research output: Contribution to journalArticle

Aishima, Shinichi ; Nishihara, Yunosuke ; Tsujita, Eiji ; Taguchi, Kenichi ; Soejima, Yuji ; Taketomi, Akinobu ; Ikeda, Yasuharu ; Maehara, Yoshihiko ; Tsuneyoshi, Masazumi. / Biliary neoplasia with extensive intraductal spread associated with liver cirrhosis : a hitherto unreported variant of biliary intraepithelial neoplasia. In: Human Pathology. 2008 ; Vol. 39, No. 6. pp. 939-947.
@article{160b0ce5b05342a1b098bbcd1bfaeaa5,
title = "Biliary neoplasia with extensive intraductal spread associated with liver cirrhosis: a hitherto unreported variant of biliary intraepithelial neoplasia",
abstract = "We describe the histopathologic features of 2 cases of biliary neoplasia with extensive intraductal spread arising in liver cirrhosis. The prevalence of this type of biliary neoplasia may be 0.4{\%} from the review of 468 cases of cirrhotic liver. Histologic analysis revealed that the micropapillary proliferation of the atypical biliary epithelium composed of columnar cells with enlarged nuclei diffusely extended superficially from the septal intrahepatic bile duct to the reactive ductules associated with liver cirrhosis. Both cases exhibited prominent fibrous or sclerotic stroma near the biliary lesion. Immunohistochemical analysis revealed a characteristic cytokeratin and mucin expression pattern (CK7++, CK19++, CK20+, MUC1+/-, MUC2-, MUC5AC+, MUC6-). The tumor cytoplasm was focally positive for laminin γ2 together with linear staining of the basement membrane. Proliferative activity confirmed by Ki67 staining was relatively high. Both patients were disease-free for 3 years after the operation. We believe that the possibility of biliary neoplasia with extensive intraductal spread should be considered to be a variant of biliary intraepithelial neoplasia.",
author = "Shinichi Aishima and Yunosuke Nishihara and Eiji Tsujita and Kenichi Taguchi and Yuji Soejima and Akinobu Taketomi and Yasuharu Ikeda and Yoshihiko Maehara and Masazumi Tsuneyoshi",
year = "2008",
month = "6",
day = "1",
doi = "10.1016/j.humpath.2007.10.031",
language = "English",
volume = "39",
pages = "939--947",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Biliary neoplasia with extensive intraductal spread associated with liver cirrhosis

T2 - a hitherto unreported variant of biliary intraepithelial neoplasia

AU - Aishima, Shinichi

AU - Nishihara, Yunosuke

AU - Tsujita, Eiji

AU - Taguchi, Kenichi

AU - Soejima, Yuji

AU - Taketomi, Akinobu

AU - Ikeda, Yasuharu

AU - Maehara, Yoshihiko

AU - Tsuneyoshi, Masazumi

PY - 2008/6/1

Y1 - 2008/6/1

N2 - We describe the histopathologic features of 2 cases of biliary neoplasia with extensive intraductal spread arising in liver cirrhosis. The prevalence of this type of biliary neoplasia may be 0.4% from the review of 468 cases of cirrhotic liver. Histologic analysis revealed that the micropapillary proliferation of the atypical biliary epithelium composed of columnar cells with enlarged nuclei diffusely extended superficially from the septal intrahepatic bile duct to the reactive ductules associated with liver cirrhosis. Both cases exhibited prominent fibrous or sclerotic stroma near the biliary lesion. Immunohistochemical analysis revealed a characteristic cytokeratin and mucin expression pattern (CK7++, CK19++, CK20+, MUC1+/-, MUC2-, MUC5AC+, MUC6-). The tumor cytoplasm was focally positive for laminin γ2 together with linear staining of the basement membrane. Proliferative activity confirmed by Ki67 staining was relatively high. Both patients were disease-free for 3 years after the operation. We believe that the possibility of biliary neoplasia with extensive intraductal spread should be considered to be a variant of biliary intraepithelial neoplasia.

AB - We describe the histopathologic features of 2 cases of biliary neoplasia with extensive intraductal spread arising in liver cirrhosis. The prevalence of this type of biliary neoplasia may be 0.4% from the review of 468 cases of cirrhotic liver. Histologic analysis revealed that the micropapillary proliferation of the atypical biliary epithelium composed of columnar cells with enlarged nuclei diffusely extended superficially from the septal intrahepatic bile duct to the reactive ductules associated with liver cirrhosis. Both cases exhibited prominent fibrous or sclerotic stroma near the biliary lesion. Immunohistochemical analysis revealed a characteristic cytokeratin and mucin expression pattern (CK7++, CK19++, CK20+, MUC1+/-, MUC2-, MUC5AC+, MUC6-). The tumor cytoplasm was focally positive for laminin γ2 together with linear staining of the basement membrane. Proliferative activity confirmed by Ki67 staining was relatively high. Both patients were disease-free for 3 years after the operation. We believe that the possibility of biliary neoplasia with extensive intraductal spread should be considered to be a variant of biliary intraepithelial neoplasia.

UR - http://www.scopus.com/inward/record.url?scp=44649126601&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44649126601&partnerID=8YFLogxK

U2 - 10.1016/j.humpath.2007.10.031

DO - 10.1016/j.humpath.2007.10.031

M3 - Article

C2 - 18430455

AN - SCOPUS:44649126601

VL - 39

SP - 939

EP - 947

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 6

ER -