Bilirubin, cardiovascular diseases and cancer: Epidemiological perspectives

Ohnaka Keizo, Suminori Kono

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Owing to a potent antioxidant property of bilirubin, a growing interest has been drawn to the potential protective effects of bilirubin against oxidative stress-related diseases. This article evaluates associations of bilirubin with atherosclerotic diseases and cancer. Serum bilirubin has consistently been shown to be inversely associated with diverse atherosclerotic diseases, mostly among men in different populations. A limited number of prospective studies have shown a U-shaped or reversed J-shaped relationship between bilirubin and coronary heart disease in men and no evident association in women. Few studies have provided evidence supportive of a protective association between bilirubin and cancer risk. The findings on bilirubin-related genetic polymorphisms are inconsistent in relation to coronary heart disease and cancer.

Original languageEnglish
Pages (from-to)891-904
Number of pages14
JournalExpert Review of Endocrinology and Metabolism
Volume5
Issue number6
DOIs
Publication statusPublished - Jan 1 2010

Fingerprint

Bilirubin
Cardiovascular Diseases
Neoplasms
Coronary Disease
Heart Neoplasms
Genetic Polymorphisms
Oxidative Stress
Antioxidants
Prospective Studies
Serum
Population

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

Bilirubin, cardiovascular diseases and cancer : Epidemiological perspectives. / Keizo, Ohnaka; Kono, Suminori.

In: Expert Review of Endocrinology and Metabolism, Vol. 5, No. 6, 01.01.2010, p. 891-904.

Research output: Contribution to journalReview article

@article{a090296d4b4f46c3ad58f3ea480e4372,
title = "Bilirubin, cardiovascular diseases and cancer: Epidemiological perspectives",
abstract = "Owing to a potent antioxidant property of bilirubin, a growing interest has been drawn to the potential protective effects of bilirubin against oxidative stress-related diseases. This article evaluates associations of bilirubin with atherosclerotic diseases and cancer. Serum bilirubin has consistently been shown to be inversely associated with diverse atherosclerotic diseases, mostly among men in different populations. A limited number of prospective studies have shown a U-shaped or reversed J-shaped relationship between bilirubin and coronary heart disease in men and no evident association in women. Few studies have provided evidence supportive of a protective association between bilirubin and cancer risk. The findings on bilirubin-related genetic polymorphisms are inconsistent in relation to coronary heart disease and cancer.",
author = "Ohnaka Keizo and Suminori Kono",
year = "2010",
month = "1",
day = "1",
doi = "10.1586/eem.10.65",
language = "English",
volume = "5",
pages = "891--904",
journal = "Expert Review of Endocrinology and Metabolism",
issn = "1744-6651",
publisher = "Expert Reviews Ltd.",
number = "6",

}

TY - JOUR

T1 - Bilirubin, cardiovascular diseases and cancer

T2 - Epidemiological perspectives

AU - Keizo, Ohnaka

AU - Kono, Suminori

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Owing to a potent antioxidant property of bilirubin, a growing interest has been drawn to the potential protective effects of bilirubin against oxidative stress-related diseases. This article evaluates associations of bilirubin with atherosclerotic diseases and cancer. Serum bilirubin has consistently been shown to be inversely associated with diverse atherosclerotic diseases, mostly among men in different populations. A limited number of prospective studies have shown a U-shaped or reversed J-shaped relationship between bilirubin and coronary heart disease in men and no evident association in women. Few studies have provided evidence supportive of a protective association between bilirubin and cancer risk. The findings on bilirubin-related genetic polymorphisms are inconsistent in relation to coronary heart disease and cancer.

AB - Owing to a potent antioxidant property of bilirubin, a growing interest has been drawn to the potential protective effects of bilirubin against oxidative stress-related diseases. This article evaluates associations of bilirubin with atherosclerotic diseases and cancer. Serum bilirubin has consistently been shown to be inversely associated with diverse atherosclerotic diseases, mostly among men in different populations. A limited number of prospective studies have shown a U-shaped or reversed J-shaped relationship between bilirubin and coronary heart disease in men and no evident association in women. Few studies have provided evidence supportive of a protective association between bilirubin and cancer risk. The findings on bilirubin-related genetic polymorphisms are inconsistent in relation to coronary heart disease and cancer.

UR - http://www.scopus.com/inward/record.url?scp=78649380553&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649380553&partnerID=8YFLogxK

U2 - 10.1586/eem.10.65

DO - 10.1586/eem.10.65

M3 - Review article

AN - SCOPUS:78649380553

VL - 5

SP - 891

EP - 904

JO - Expert Review of Endocrinology and Metabolism

JF - Expert Review of Endocrinology and Metabolism

SN - 1744-6651

IS - 6

ER -