Bilirubin induces discoloration and hypodontia on tooth

Haruyoshi Yamaza

doi:10.1016/j.pdj.2021.11.002

Bilirubin induces discoloration and hypodontia on tooth

Haruyoshi Yamaza

Oral health, growth and development

Research output: Contribution to journal › Review article › peer-review

Abstract

Background: Systematic and local factors give various effects to teeth during odontogenesis or after eruption. Discoloration of teeth is also caused by systematic and local factors and sometimes leads to esthetic and biological problems. Bilirubin is the product of heme metabolism and causes greenish discoloration and hypodontia with its high concentration in blood. Objective: This review aimed to indicate effects of bilirubin on odontogenesis with in vitro model established by stem cells of human exfoliated deciduous teeth (SHED). Results: Recent studies showed that bilirubin suppressed cell proliferation and promoted cell death in SHED with alteration of their involved-signaling pathways. In addition, it was indicated that pamidronate recovered bilirubin-altered signaling pathways and bilirubin-impaired dentinogenic function of SHED. Conclusion: SHED could be tool to established human in vitro model to elucidate human pathogenesis and for screening to pick up the candidates of medicines.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	pediatric dental journal
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.pdj.2021.11.002
Publication status	Published - Apr 2022

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Dentistry (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pdj.2021.11.002

Cite this

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title = "Bilirubin induces discoloration and hypodontia on tooth",

abstract = "Background: Systematic and local factors give various effects to teeth during odontogenesis or after eruption. Discoloration of teeth is also caused by systematic and local factors and sometimes leads to esthetic and biological problems. Bilirubin is the product of heme metabolism and causes greenish discoloration and hypodontia with its high concentration in blood. Objective: This review aimed to indicate effects of bilirubin on odontogenesis with in vitro model established by stem cells of human exfoliated deciduous teeth (SHED). Results: Recent studies showed that bilirubin suppressed cell proliferation and promoted cell death in SHED with alteration of their involved-signaling pathways. In addition, it was indicated that pamidronate recovered bilirubin-altered signaling pathways and bilirubin-impaired dentinogenic function of SHED. Conclusion: SHED could be tool to established human in vitro model to elucidate human pathogenesis and for screening to pick up the candidates of medicines.",

author = "Haruyoshi Yamaza",

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doi = "10.1016/j.pdj.2021.11.002",

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T1 - Bilirubin induces discoloration and hypodontia on tooth

AU - Yamaza, Haruyoshi

PY - 2022/4

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N2 - Background: Systematic and local factors give various effects to teeth during odontogenesis or after eruption. Discoloration of teeth is also caused by systematic and local factors and sometimes leads to esthetic and biological problems. Bilirubin is the product of heme metabolism and causes greenish discoloration and hypodontia with its high concentration in blood. Objective: This review aimed to indicate effects of bilirubin on odontogenesis with in vitro model established by stem cells of human exfoliated deciduous teeth (SHED). Results: Recent studies showed that bilirubin suppressed cell proliferation and promoted cell death in SHED with alteration of their involved-signaling pathways. In addition, it was indicated that pamidronate recovered bilirubin-altered signaling pathways and bilirubin-impaired dentinogenic function of SHED. Conclusion: SHED could be tool to established human in vitro model to elucidate human pathogenesis and for screening to pick up the candidates of medicines.

AB - Background: Systematic and local factors give various effects to teeth during odontogenesis or after eruption. Discoloration of teeth is also caused by systematic and local factors and sometimes leads to esthetic and biological problems. Bilirubin is the product of heme metabolism and causes greenish discoloration and hypodontia with its high concentration in blood. Objective: This review aimed to indicate effects of bilirubin on odontogenesis with in vitro model established by stem cells of human exfoliated deciduous teeth (SHED). Results: Recent studies showed that bilirubin suppressed cell proliferation and promoted cell death in SHED with alteration of their involved-signaling pathways. In addition, it was indicated that pamidronate recovered bilirubin-altered signaling pathways and bilirubin-impaired dentinogenic function of SHED. Conclusion: SHED could be tool to established human in vitro model to elucidate human pathogenesis and for screening to pick up the candidates of medicines.

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Bilirubin induces discoloration and hypodontia on tooth

Abstract

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