Bio and nanotechnological strategies for tumor-targeted gene therapy

Jeong Hun Kang, Riki Toita, Yoshiki Katayama

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Gene therapy is a new medical approach for the treatment of tumors. For safe and efficient gene therapy, therapeutic genes need to be delivered efficiently into the target tumor cells. Development of gene delivery systems to specifically recognize and target tumor cells and to distinguish them from normal cells, especially in the same tissue or organ, is one of the most important issues regarding the present gene delivery methodologies. The enhanced permeability and retention (EPR) effect using the characteristics of angiogenic tumor blood vessels, as well as gene delivery systems recognizing hyperactivated receptors or intracellular signals, is broadly applied to tumor-targeted gene therapy. In addition, bacterial vectors can be a useful means for targeting hypoxic or anoxic regions of a tumor.

Original languageEnglish
Pages (from-to)757-763
Number of pages7
JournalBiotechnology Advances
Volume28
Issue number6
DOIs
Publication statusPublished - Nov 1 2010

Fingerprint

Gene therapy
Genetic Therapy
Tumors
Genes
Gene Transfer Techniques
Neoplasms
Vascular Tissue Neoplasms
Cells
Blood vessels
Permeability
Tissue
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Cite this

Bio and nanotechnological strategies for tumor-targeted gene therapy. / Kang, Jeong Hun; Toita, Riki; Katayama, Yoshiki.

In: Biotechnology Advances, Vol. 28, No. 6, 01.11.2010, p. 757-763.

Research output: Contribution to journalReview article

Kang, Jeong Hun ; Toita, Riki ; Katayama, Yoshiki. / Bio and nanotechnological strategies for tumor-targeted gene therapy. In: Biotechnology Advances. 2010 ; Vol. 28, No. 6. pp. 757-763.
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