Bioactive fluorinated derivative of amphotericin B

Nobuaki Matsumori, Yuichi Umegawa, Tohru Oishi, Michio Murata

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

The first stably fluorinated derivative of amphotericin B (2) with a fluorine atom in the macrolide skeleton was synthesized using an electrophilic fluorination reagent, Selectfluor®. The derivative 2 showed hemolytic, K+ permeable, and antifungal activities similar to those of AmB and thus was expected to be a powerful tool for NMR-based investigations on the mechanism of ion-channel formation by amphotericin B.

Original languageEnglish
Pages (from-to)3565-3567
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number15
DOIs
Publication statusPublished - Aug 1 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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