Bioactive fluorinated derivative of amphotericin B

Nobuaki Matsumori, Yuichi Umegawa, Tohru Oishi, Michio Murata

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The first stably fluorinated derivative of amphotericin B (2) with a fluorine atom in the macrolide skeleton was synthesized using an electrophilic fluorination reagent, Selectfluor®. The derivative 2 showed hemolytic, K+ permeable, and antifungal activities similar to those of AmB and thus was expected to be a powerful tool for NMR-based investigations on the mechanism of ion-channel formation by amphotericin B.

Original languageEnglish
Pages (from-to)3565-3567
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number15
DOIs
Publication statusPublished - Aug 1 2005
Externally publishedYes

Fingerprint

Amphotericin B
Derivatives
Fluorination
Fluorine
Halogenation
Macrolides
Ion Channels
Skeleton
Nuclear magnetic resonance
Atoms
selectfluor

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Bioactive fluorinated derivative of amphotericin B. / Matsumori, Nobuaki; Umegawa, Yuichi; Oishi, Tohru; Murata, Michio.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 15, 01.08.2005, p. 3565-3567.

Research output: Contribution to journalArticle

Matsumori, Nobuaki ; Umegawa, Yuichi ; Oishi, Tohru ; Murata, Michio. / Bioactive fluorinated derivative of amphotericin B. In: Bioorganic and Medicinal Chemistry Letters. 2005 ; Vol. 15, No. 15. pp. 3565-3567.
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