Bioactive steroidal saponins from Smilax medica

M. Sautour, T. Miyamoto, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Two new spirostanol saponins (1 and 2) were isolated from the roots of Smilax medica, together with the known smilagenin 3-O-β-D-glucopyranoside (3). Their structures were determined by spectroscopic methods including 1D- and 2D-NMR experiments. Compounds 1 and 2 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs between 6.25 and 50 μg/mL) whereas 3 was inactive.

Original languageEnglish
Pages (from-to)667-670
Number of pages4
JournalPlanta medica
Volume72
Issue number7
DOIs
Publication statusPublished - Jun 1 2006

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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