Biochemical and molecular mechanisms in the development of diabetic vascular complications

George L. King, Makoto Kunisaki, Yoshihiko Nishio, Toyoshi Inoguchi, Teruo Shiba, Pu Xia

    Research output: Contribution to journalArticle

    106 Citations (Scopus)

    Abstract

    Hyperglycemia is the major causal factor in the development of diabetic vascular complications. The mechanism by which hyperglycemia causes the complications is not clear; however, it is very likely that hyperglycemia is mediating its adverse effects through multiple mechanisms. We have summarized some of these mechanisms in this review, with particular attention to the effect of hyperglycemia on the activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway. We have reviewed existing information regarding various vascular tissues that show increased DAG and PKC levels. In addition, the mechanism by which hyperglycemia increases DAG as well as the cellular physiological consequences on the activation of PKC have been reviewed.

    Original languageEnglish
    Pages (from-to)S105-S108
    JournalDiabetes
    Volume45
    Issue number3 SUPPL.
    Publication statusPublished - Dec 1 1996

    Fingerprint

    Diabetic Angiopathies
    Hyperglycemia
    Diacylglycerol Kinase
    Protein Kinase C
    Diglycerides
    Blood Vessels

    All Science Journal Classification (ASJC) codes

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism

    Cite this

    King, G. L., Kunisaki, M., Nishio, Y., Inoguchi, T., Shiba, T., & Xia, P. (1996). Biochemical and molecular mechanisms in the development of diabetic vascular complications. Diabetes, 45(3 SUPPL.), S105-S108.

    Biochemical and molecular mechanisms in the development of diabetic vascular complications. / King, George L.; Kunisaki, Makoto; Nishio, Yoshihiko; Inoguchi, Toyoshi; Shiba, Teruo; Xia, Pu.

    In: Diabetes, Vol. 45, No. 3 SUPPL., 01.12.1996, p. S105-S108.

    Research output: Contribution to journalArticle

    King, GL, Kunisaki, M, Nishio, Y, Inoguchi, T, Shiba, T & Xia, P 1996, 'Biochemical and molecular mechanisms in the development of diabetic vascular complications', Diabetes, vol. 45, no. 3 SUPPL., pp. S105-S108.
    King GL, Kunisaki M, Nishio Y, Inoguchi T, Shiba T, Xia P. Biochemical and molecular mechanisms in the development of diabetic vascular complications. Diabetes. 1996 Dec 1;45(3 SUPPL.):S105-S108.
    King, George L. ; Kunisaki, Makoto ; Nishio, Yoshihiko ; Inoguchi, Toyoshi ; Shiba, Teruo ; Xia, Pu. / Biochemical and molecular mechanisms in the development of diabetic vascular complications. In: Diabetes. 1996 ; Vol. 45, No. 3 SUPPL. pp. S105-S108.
    @article{e6582b5d11d44de999321c46f9b22d99,
    title = "Biochemical and molecular mechanisms in the development of diabetic vascular complications",
    abstract = "Hyperglycemia is the major causal factor in the development of diabetic vascular complications. The mechanism by which hyperglycemia causes the complications is not clear; however, it is very likely that hyperglycemia is mediating its adverse effects through multiple mechanisms. We have summarized some of these mechanisms in this review, with particular attention to the effect of hyperglycemia on the activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway. We have reviewed existing information regarding various vascular tissues that show increased DAG and PKC levels. In addition, the mechanism by which hyperglycemia increases DAG as well as the cellular physiological consequences on the activation of PKC have been reviewed.",
    author = "King, {George L.} and Makoto Kunisaki and Yoshihiko Nishio and Toyoshi Inoguchi and Teruo Shiba and Pu Xia",
    year = "1996",
    month = "12",
    day = "1",
    language = "English",
    volume = "45",
    pages = "S105--S108",
    journal = "Diabetes",
    issn = "0012-1797",
    publisher = "医学出版",
    number = "3 SUPPL.",

    }

    TY - JOUR

    T1 - Biochemical and molecular mechanisms in the development of diabetic vascular complications

    AU - King, George L.

    AU - Kunisaki, Makoto

    AU - Nishio, Yoshihiko

    AU - Inoguchi, Toyoshi

    AU - Shiba, Teruo

    AU - Xia, Pu

    PY - 1996/12/1

    Y1 - 1996/12/1

    N2 - Hyperglycemia is the major causal factor in the development of diabetic vascular complications. The mechanism by which hyperglycemia causes the complications is not clear; however, it is very likely that hyperglycemia is mediating its adverse effects through multiple mechanisms. We have summarized some of these mechanisms in this review, with particular attention to the effect of hyperglycemia on the activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway. We have reviewed existing information regarding various vascular tissues that show increased DAG and PKC levels. In addition, the mechanism by which hyperglycemia increases DAG as well as the cellular physiological consequences on the activation of PKC have been reviewed.

    AB - Hyperglycemia is the major causal factor in the development of diabetic vascular complications. The mechanism by which hyperglycemia causes the complications is not clear; however, it is very likely that hyperglycemia is mediating its adverse effects through multiple mechanisms. We have summarized some of these mechanisms in this review, with particular attention to the effect of hyperglycemia on the activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway. We have reviewed existing information regarding various vascular tissues that show increased DAG and PKC levels. In addition, the mechanism by which hyperglycemia increases DAG as well as the cellular physiological consequences on the activation of PKC have been reviewed.

    UR - http://www.scopus.com/inward/record.url?scp=0029975352&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0029975352&partnerID=8YFLogxK

    M3 - Article

    C2 - 8674872

    AN - SCOPUS:0029975352

    VL - 45

    SP - S105-S108

    JO - Diabetes

    JF - Diabetes

    SN - 0012-1797

    IS - 3 SUPPL.

    ER -