TY - JOUR
T1 - Biochemical Evaluation of Copper Compounds Derived from O- and N-/O- Donor Ligands
AU - Akhtar, Muhammad Nadeem
AU - Shahid, Muhammad
AU - Sadakiyo, Masaaki
AU - Ikram, Muhammad
AU - Rehman, Sadia
AU - Ahmed, Irshad
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Compounds [CuII 2(benz)4(Hbenz)2] (1) and [CuII(ppa)2(H2O)2]n (2), where benz = benzoate and ppa = 3-pyridinepropionic acid, were synthesized and studied for their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and the inhibition of enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX), urease, chymotrypsin and α-glucosidase. The synthesized compounds were also studied by hemolytic method for their cytotoxicity and found to be low-toxicity substances. For AChE inhibition, compound 2 showed IC50 = 31.22 ± 0.45 μM, as compared to compound 1with IC50 = 36.52 ± 0.44 μM. Both compounds showed comparably low activity against BChE and were also active against urease, but compound 1 exhibited selective anti-urease activity. The anti-α-glucosidase activity of both compounds was comparable with that of standard drug used.
AB - Compounds [CuII 2(benz)4(Hbenz)2] (1) and [CuII(ppa)2(H2O)2]n (2), where benz = benzoate and ppa = 3-pyridinepropionic acid, were synthesized and studied for their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and the inhibition of enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX), urease, chymotrypsin and α-glucosidase. The synthesized compounds were also studied by hemolytic method for their cytotoxicity and found to be low-toxicity substances. For AChE inhibition, compound 2 showed IC50 = 31.22 ± 0.45 μM, as compared to compound 1with IC50 = 36.52 ± 0.44 μM. Both compounds showed comparably low activity against BChE and were also active against urease, but compound 1 exhibited selective anti-urease activity. The anti-α-glucosidase activity of both compounds was comparable with that of standard drug used.
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U2 - 10.1007/s11094-017-1596-1
DO - 10.1007/s11094-017-1596-1
M3 - Article
AN - SCOPUS:85026510812
VL - 51
SP - 272
EP - 276
JO - Pharmaceutical Chemistry Journal
JF - Pharmaceutical Chemistry Journal
SN - 0091-150X
IS - 4
ER -