Biochemical Evaluation of Copper Compounds Derived from O- and N-/O- Donor Ligands

Muhammad Nadeem Akhtar; Muhammad Shahid; Masaaki Sadakiyo; Muhammad Ikram; Sadia Rehman; Irshad Ahmed

doi:10.1007/s11094-017-1596-1

Biochemical Evaluation of Copper Compounds Derived from O- and N-/O- Donor Ligands

Muhammad Nadeem Akhtar, Muhammad Shahid, Masaaki Sadakiyo, Muhammad Ikram, Sadia Rehman, Irshad Ahmed

Research output: Contribution to journal › Article › peer-review

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Abstract

Compounds [Cu^II ₂(benz)₄(Hbenz)₂] (1) and [Cu^II(ppa)₂(H₂O)₂]_n (2), where benz = benzoate and ppa = 3-pyridinepropionic acid, were synthesized and studied for their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and the inhibition of enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX), urease, chymotrypsin and α-glucosidase. The synthesized compounds were also studied by hemolytic method for their cytotoxicity and found to be low-toxicity substances. For AChE inhibition, compound 2 showed IC₅₀ = 31.22 ± 0.45 μM, as compared to compound 1with IC₅₀ = 36.52 ± 0.44 μM. Both compounds showed comparably low activity against BChE and were also active against urease, but compound 1 exhibited selective anti-urease activity. The anti-α-glucosidase activity of both compounds was comparable with that of standard drug used.

Original language	English
Pages (from-to)	272-276
Number of pages	5
Journal	Pharmaceutical Chemistry Journal
Volume	51
Issue number	4
DOIs	https://doi.org/10.1007/s11094-017-1596-1
Publication status	Published - Jul 1 2017

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

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title = "Biochemical Evaluation of Copper Compounds Derived from O- and N-/O- Donor Ligands",

abstract = "Compounds [CuII 2(benz)4(Hbenz)2] (1) and [CuII(ppa)2(H2O)2]n (2), where benz = benzoate and ppa = 3-pyridinepropionic acid, were synthesized and studied for their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and the inhibition of enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX), urease, chymotrypsin and α-glucosidase. The synthesized compounds were also studied by hemolytic method for their cytotoxicity and found to be low-toxicity substances. For AChE inhibition, compound 2 showed IC50 = 31.22 ± 0.45 μM, as compared to compound 1with IC50 = 36.52 ± 0.44 μM. Both compounds showed comparably low activity against BChE and were also active against urease, but compound 1 exhibited selective anti-urease activity. The anti-α-glucosidase activity of both compounds was comparable with that of standard drug used.",

author = "Akhtar, {Muhammad Nadeem} and Muhammad Shahid and Masaaki Sadakiyo and Muhammad Ikram and Sadia Rehman and Irshad Ahmed",

year = "2017",

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doi = "10.1007/s11094-017-1596-1",

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AU - Akhtar, Muhammad Nadeem

AU - Shahid, Muhammad

AU - Sadakiyo, Masaaki

AU - Ikram, Muhammad

AU - Rehman, Sadia

AU - Ahmed, Irshad

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Compounds [CuII 2(benz)4(Hbenz)2] (1) and [CuII(ppa)2(H2O)2]n (2), where benz = benzoate and ppa = 3-pyridinepropionic acid, were synthesized and studied for their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and the inhibition of enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX), urease, chymotrypsin and α-glucosidase. The synthesized compounds were also studied by hemolytic method for their cytotoxicity and found to be low-toxicity substances. For AChE inhibition, compound 2 showed IC50 = 31.22 ± 0.45 μM, as compared to compound 1with IC50 = 36.52 ± 0.44 μM. Both compounds showed comparably low activity against BChE and were also active against urease, but compound 1 exhibited selective anti-urease activity. The anti-α-glucosidase activity of both compounds was comparable with that of standard drug used.

AB - Compounds [CuII 2(benz)4(Hbenz)2] (1) and [CuII(ppa)2(H2O)2]n (2), where benz = benzoate and ppa = 3-pyridinepropionic acid, were synthesized and studied for their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and the inhibition of enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX), urease, chymotrypsin and α-glucosidase. The synthesized compounds were also studied by hemolytic method for their cytotoxicity and found to be low-toxicity substances. For AChE inhibition, compound 2 showed IC50 = 31.22 ± 0.45 μM, as compared to compound 1with IC50 = 36.52 ± 0.44 μM. Both compounds showed comparably low activity against BChE and were also active against urease, but compound 1 exhibited selective anti-urease activity. The anti-α-glucosidase activity of both compounds was comparable with that of standard drug used.

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Biochemical Evaluation of Copper Compounds Derived from O- and N-/O- Donor Ligands

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