Biochemical Evaluation of Copper Compounds Derived from O- and N-/O- Donor Ligands

Muhammad Nadeem Akhtar, Muhammad Shahid, Masaaki Sadakiyo, Muhammad Ikram, Sadia Rehman, Irshad Ahmed

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    Compounds [CuII 2(benz)4(Hbenz)2] (1) and [CuII(ppa)2(H2O)2]n (2), where benz = benzoate and ppa = 3-pyridinepropionic acid, were synthesized and studied for their 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and the inhibition of enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX), urease, chymotrypsin and α-glucosidase. The synthesized compounds were also studied by hemolytic method for their cytotoxicity and found to be low-toxicity substances. For AChE inhibition, compound 2 showed IC50 = 31.22 ± 0.45 μM, as compared to compound 1with IC50 = 36.52 ± 0.44 μM. Both compounds showed comparably low activity against BChE and were also active against urease, but compound 1 exhibited selective anti-urease activity. The anti-α-glucosidase activity of both compounds was comparable with that of standard drug used.

    Original languageEnglish
    Pages (from-to)272-276
    Number of pages5
    JournalPharmaceutical Chemistry Journal
    Volume51
    Issue number4
    DOIs
    Publication statusPublished - Jul 1 2017

    All Science Journal Classification (ASJC) codes

    • Pharmacology
    • Drug Discovery

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