Biochemical studies on 2-deoxy-scyllo-inosose, an early intermediate in the biosynthesis of 2-deoxystreptamine I. Chemical synthesis of 2-deoxy-5c7llo-inosose and [2,2-2h2]-2-deoxy-scfllo-inosose

Noriaki Yamauchi, Katsumi Kakinuma

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

A practical preparative method for 2-deoxy-scyllo-inosose, the earliest key intermediate leading to 2-deoxystreptamine, was devised as a prerequisite to more detailed biochemical studies on the biosynthesis of 2-deoxystreptamine. [2,2-2H2]-2-Deoxy-scyllo-inosose was also synthesized through a modified Ferrier reaction.

Original languageEnglish
Pages (from-to)756-766
Number of pages11
JournalThe Journal of Antibiotics
Volume45
Issue number5
DOIs
Publication statusPublished - 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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