Biochemical studies on 2-deoxy-scyllo-inosose, an early intermediate in the biosynthesis of 2-deoxystreptamine ii. Quantitative analysis of 2-deoxy-sc7llo-inosose

Noriaki Yamauchi, Katsumi Kakinuma

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

A practical quantitative analysis of 2-deoxy-scyllo-inosose by means of GC-MS selected-ion monitoring (SIM) was exploited in order to assay the enzymatic 2-deoxy-scyllo-inosose formation, the first stage of the 2-deoxystreptamine biosynthesis. Mass spectral fragmentations of 2-deoxy-scyllo-inosose tetra-O-trimethylsilyl (TMS) ether was also investigated by the use of [2,2-2H2]-2-deoxy-scyllo-inosose.

Original languageEnglish
Pages (from-to)767-773
Number of pages7
JournalThe Journal of Antibiotics
Volume45
Issue number5
DOIs
Publication statusPublished - 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Fingerprint Dive into the research topics of 'Biochemical studies on 2-deoxy-scyllo-inosose, an early intermediate in the biosynthesis of 2-deoxystreptamine ii. Quantitative analysis of 2-deoxy-sc7llo-inosose'. Together they form a unique fingerprint.

Cite this