TY - JOUR
T1 - Biochemical switching device
T2 - biomimetic approach and application to neural network study
AU - Okamoto, Masahiro
N1 - Funding Information:
This research is supported by the NISSAN SCIENCE FOUNDATION, Japan. I thank Professor Katsuya Hayashi of Kyushu University for his encouragement of this research. A part of this research was done in collaboration with Drs. Yoichi Aso, Satoru Kuhara, Ms. Michiko Tsukiji-Ishikita, Ms. Atsuko Katsurayama-Mizota and Mr. Toshio Sakai of Kyushu University.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1992/6/1
Y1 - 1992/6/1
N2 - There are many examples of enzymes that share substrates or cofactors in a cyclic manner. Techniques have been developed that use cyclic enzyme systems to assay quantitatively small amounts of biochemical substances (cofactor, substrate), however, only a few studies of the control of these systems have been published. The author previously showed with computer simulations that cyclic enzyme systems have the reliability of on-off types of operation (McCulloch-Pitts' neuronic equation) capable of storing short-memory, and the applicability for a switching circuit in a biocomputer. This paper introduces a unique switching mechanism of cyclic enzyme system (basic switching element), and next, building the integrated biochemical switching system being composed of the basic switching element, shows the physiological phenomenon termed 'selective elimination of synapses' generally produced as a result of low-frequency train of electrical stimuli to the synapses (Kuroda, Y. (1989) Neurochem. Int. 14, 309-319).
AB - There are many examples of enzymes that share substrates or cofactors in a cyclic manner. Techniques have been developed that use cyclic enzyme systems to assay quantitatively small amounts of biochemical substances (cofactor, substrate), however, only a few studies of the control of these systems have been published. The author previously showed with computer simulations that cyclic enzyme systems have the reliability of on-off types of operation (McCulloch-Pitts' neuronic equation) capable of storing short-memory, and the applicability for a switching circuit in a biocomputer. This paper introduces a unique switching mechanism of cyclic enzyme system (basic switching element), and next, building the integrated biochemical switching system being composed of the basic switching element, shows the physiological phenomenon termed 'selective elimination of synapses' generally produced as a result of low-frequency train of electrical stimuli to the synapses (Kuroda, Y. (1989) Neurochem. Int. 14, 309-319).
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U2 - 10.1016/0168-1656(92)90064-G
DO - 10.1016/0168-1656(92)90064-G
M3 - Article
C2 - 1368350
AN - SCOPUS:0026645578
SN - 0168-1656
VL - 24
SP - 109
EP - 127
JO - Journal of Biotechnology
JF - Journal of Biotechnology
IS - 1
ER -