Biocompatibility of hydrophilicity improved apatite cement

Hydrophilicity of apatite cement was increased after O3 gas treatment on apatite cement (AC) powder. It results on the improvement of the handling and mechanical properties of set AC. Behavior of osteoblastic cells to O3-treated set AC was evaluated including initial cell attachment, morphology of the attached cells and proliferation using rat bone marrow cell (RBM). Cells’ response to the set AC was the same regardless of O3 treatment. The cells well attached and spread with filopodial extensions even over the O3-treated set AC specimens. The rates of cell proliferation on set AC were also the same regardless of O3 treatment. The result indicated O3 treatment of AC powder would not affect to the osteoblast cell response of set AC.