Biodegradable chitosan-silicate porous hybrids for drug delivery

Y. Shirosaki, K. Tsuru, S. Hayakawa, A. Osaka

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Porous chitosan-silicate hybrids were prepared by freeze-drying the precursor sol solutions synthesized from chitosan and 3- glycidoxypropyltrimethoxysilane (GPTMS). Degradability of and the release of cytochrome C in to phosphate buffer saline solution (PBS) were examined as a function of the GPTMS content. The hybrids were less degradable with larger GPTMS contents, and the cytochrome C release profile was so controllable as to give either burst release or slow one due to the GPTMS content. Thus, the present porous chitosan-silicate hybrids were considered applicable to drug delivery systems.

Original languageEnglish
Pages (from-to)1219-1222
Number of pages4
JournalKey Engineering Materials
Volume361-363 II
Publication statusPublished - Jan 22 2008

Fingerprint

Silicates
Chitosan
Drug delivery
Cytochromes
Proteins
Polymethyl Methacrylate
Sols
Sodium Chloride
Drying
Buffers
Phosphates

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Shirosaki, Y., Tsuru, K., Hayakawa, S., & Osaka, A. (2008). Biodegradable chitosan-silicate porous hybrids for drug delivery. Key Engineering Materials, 361-363 II, 1219-1222.

Biodegradable chitosan-silicate porous hybrids for drug delivery. / Shirosaki, Y.; Tsuru, K.; Hayakawa, S.; Osaka, A.

In: Key Engineering Materials, Vol. 361-363 II, 22.01.2008, p. 1219-1222.

Research output: Contribution to journalArticle

Shirosaki, Y, Tsuru, K, Hayakawa, S & Osaka, A 2008, 'Biodegradable chitosan-silicate porous hybrids for drug delivery', Key Engineering Materials, vol. 361-363 II, pp. 1219-1222.
Shirosaki Y, Tsuru K, Hayakawa S, Osaka A. Biodegradable chitosan-silicate porous hybrids for drug delivery. Key Engineering Materials. 2008 Jan 22;361-363 II:1219-1222.
Shirosaki, Y. ; Tsuru, K. ; Hayakawa, S. ; Osaka, A. / Biodegradable chitosan-silicate porous hybrids for drug delivery. In: Key Engineering Materials. 2008 ; Vol. 361-363 II. pp. 1219-1222.
@article{d29286a7a0e2426abcb7f0598908a1b5,
title = "Biodegradable chitosan-silicate porous hybrids for drug delivery",
abstract = "Porous chitosan-silicate hybrids were prepared by freeze-drying the precursor sol solutions synthesized from chitosan and 3- glycidoxypropyltrimethoxysilane (GPTMS). Degradability of and the release of cytochrome C in to phosphate buffer saline solution (PBS) were examined as a function of the GPTMS content. The hybrids were less degradable with larger GPTMS contents, and the cytochrome C release profile was so controllable as to give either burst release or slow one due to the GPTMS content. Thus, the present porous chitosan-silicate hybrids were considered applicable to drug delivery systems.",
author = "Y. Shirosaki and K. Tsuru and S. Hayakawa and A. Osaka",
year = "2008",
month = "1",
day = "22",
language = "English",
volume = "361-363 II",
pages = "1219--1222",
journal = "Key Engineering Materials",
issn = "1013-9826",
publisher = "Trans Tech Publications",

}

TY - JOUR

T1 - Biodegradable chitosan-silicate porous hybrids for drug delivery

AU - Shirosaki, Y.

AU - Tsuru, K.

AU - Hayakawa, S.

AU - Osaka, A.

PY - 2008/1/22

Y1 - 2008/1/22

N2 - Porous chitosan-silicate hybrids were prepared by freeze-drying the precursor sol solutions synthesized from chitosan and 3- glycidoxypropyltrimethoxysilane (GPTMS). Degradability of and the release of cytochrome C in to phosphate buffer saline solution (PBS) were examined as a function of the GPTMS content. The hybrids were less degradable with larger GPTMS contents, and the cytochrome C release profile was so controllable as to give either burst release or slow one due to the GPTMS content. Thus, the present porous chitosan-silicate hybrids were considered applicable to drug delivery systems.

AB - Porous chitosan-silicate hybrids were prepared by freeze-drying the precursor sol solutions synthesized from chitosan and 3- glycidoxypropyltrimethoxysilane (GPTMS). Degradability of and the release of cytochrome C in to phosphate buffer saline solution (PBS) were examined as a function of the GPTMS content. The hybrids were less degradable with larger GPTMS contents, and the cytochrome C release profile was so controllable as to give either burst release or slow one due to the GPTMS content. Thus, the present porous chitosan-silicate hybrids were considered applicable to drug delivery systems.

UR - http://www.scopus.com/inward/record.url?scp=38149045782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38149045782&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:38149045782

VL - 361-363 II

SP - 1219

EP - 1222

JO - Key Engineering Materials

JF - Key Engineering Materials

SN - 1013-9826

ER -