Biodegradation of daunomycin post-production Wastes by Bjerkandera adusta R59

Wastes from industrial production of daunomycin belong to strongly toxic and recalcitrant substances. This study was investigated to the potential use of Bjerkandera adusta R59 as inoculum in process of daunomycin degradation in soil. Possible interactions between R59 strain and soil microorganisms during decay of wastes containing this toxic compound were also tested. Process of degradation of daunomycin post-production wastes in soil was described. Experiments were conducted in model systems. Degradation process proceeded the most efficiently in soil samples inoculated with Bjerkandera adusta R59 fungal strain, capable of decolorization of that cytostatic xenobiotic. Decrease of the waste biomass, carbon and daunomycin concentration (in daunomycin-rich pulp) as well as phenolics level (in post-production effluent) proved the effectiveness of this process, which was shown to depend on peroxidase biosynthesis in soil by B. adusta or other soil strains. Activity of this enzyme was the highest in version of experiment containing Bjerkandera adusta R59 fungal strain.