Biofunctionality of self-assembled nanolayers composed of cellulosic polymers

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Abstract

Biofunctional cellulosic interfaces were successfully designed via the self-assembly of cellulose and its derivatives whose reducing ends were selectively modified with thiosemicarbazide. The biological functions of cellulosic self-assembled monolayers (SAMs) formed on a gold surface were investigated using rat liver cells. The cells proliferated well on the cellulose SAM (cellulose I) and methylcellulose SAM, while almost no cells adhered to the regenerated cellulose film (cellulose II) and hydroxyethylcellulose SAM. In the initial cell adhesion, rat liver cells were moderately attached on the cellulose SAM even in serum-free culture, possibly suggesting specific interactions between cells and cellulose SAM with unique surface morphology. The architectural design of cellulosic nanolayers via peculiar vectorial chain immobilization is expected to provide new information for the functional development of structural polysaccharide-based biointerfaces.

Original languageEnglish
Pages (from-to)666-672
Number of pages7
JournalCarbohydrate Polymers
Volume74
Issue number3
DOIs
Publication statusPublished - Nov 4 2008

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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