Bioinert surface to protein adsorption with higher generation of dendrimer SAMs

Erino Matsumoto, Tomohiro Fukuda, Yoshiko Miura

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Interactions between proteins and biomaterial surfaces correlate with many important phenomena in biological systems. Such interactions have been used to develop various artificial biomaterials and applications, in which regulation of non-specific protein adsorption has been achieved with bioinert properties. In this research, we investigated the protein adsorption behavior of polymer brushes of dendrimer self-assembled monolayers (SAMs) with other generations. The surface adsorption properties of proteins with different p. I values were examined on gold substrates modified with poly(amidoamine) dendrimer SAMs. The amount of fibrinogen adsorption was greater than that of lysozyme, potentially because of the surface electric charge. However, as the generations increased, protein adsorption decreased regardless of the surface charge, suggesting that protein adsorption was also affected by density of terminal group.

Original languageEnglish
Pages (from-to)280-284
Number of pages5
JournalColloids and Surfaces B: Biointerfaces
Volume84
Issue number1
DOIs
Publication statusPublished - May 1 2011

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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