Bioinspired molecular transformations by biorelated metal complexes combined with electrolysis and photoredox systems

Research output: Contribution to journalArticle

Abstract

Naturally-occurring B 12(cobalamin)-dependent enzymes catalyze various molecular transformations that are of particular interest from the viewpoint of biological chemistry as well as synthetic organic chemistry. As bioorganometallic compounds are considered as intermediate for B 12-dependent reactions, those were utilized as catalysts for various molecular transformations. Using the unique property of the B 12 compound, various catalytic reactions have been developed using its model complex. Electroorganic syntheses mediated by the B 12 complex have been developed as green molecular transformations. The redox active B 12 complex shows a unique catalysis in organic synthesis such as the dechlorination of organic halides and the radical mediated isomerization reactions. The B 12 complex-photosensitizer composites have also become a green and efficient catalyst for molecular transformations. The B 12-dependent enzymes mimic reactions catalytically occurring using the B 12 complex-photosensitizer composites. In addition to the B 12 mimic reaction, novel bioinspired reactions were also developed, such as hydrogen production or alkene and alkyne reductions, and the cobalt-hydrogen complex was considered as a putative intermediate of the reactions.

Original languageEnglish
Pages (from-to)894-903
Number of pages10
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume76
Issue number9
DOIs
Publication statusPublished - Jan 1 2018

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Photosensitizing Agents
Coordination Complexes
Electrolysis
Dechlorination
Catalysts
Alkynes
Composite materials
Alkenes
Enzymes
Vitamin B 12
Hydrogen production
Isomerization
Cobalt
Catalysis
Hydrogen
Oxidation-Reduction
Organic Chemistry

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

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title = "Bioinspired molecular transformations by biorelated metal complexes combined with electrolysis and photoredox systems",
abstract = "Naturally-occurring B 12(cobalamin)-dependent enzymes catalyze various molecular transformations that are of particular interest from the viewpoint of biological chemistry as well as synthetic organic chemistry. As bioorganometallic compounds are considered as intermediate for B 12-dependent reactions, those were utilized as catalysts for various molecular transformations. Using the unique property of the B 12 compound, various catalytic reactions have been developed using its model complex. Electroorganic syntheses mediated by the B 12 complex have been developed as green molecular transformations. The redox active B 12 complex shows a unique catalysis in organic synthesis such as the dechlorination of organic halides and the radical mediated isomerization reactions. The B 12 complex-photosensitizer composites have also become a green and efficient catalyst for molecular transformations. The B 12-dependent enzymes mimic reactions catalytically occurring using the B 12 complex-photosensitizer composites. In addition to the B 12 mimic reaction, novel bioinspired reactions were also developed, such as hydrogen production or alkene and alkyne reductions, and the cobalt-hydrogen complex was considered as a putative intermediate of the reactions.",
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