Biological activity of optically active salithion and salioxon

Akinori Hirashima, Isaac Ishaaya, Ryohei Ueno, Yoshifumi Ichiyama, Shao Yong Wu, Morifusa Eto

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Salioxon enantiomers were obtained from salithion enantiomers by MCPBA oxidation. The larvicidal and adulticidal activities of salithion enantiomers, and the anti-cholinesterase activity of salioxon enantiomers were determined on house flies. On larvae, the potency of (S)(-)-salithion (LC50 = 1.1 ppm) was about two-fold higher than the (R)(+)-enantiomer (LC50 = 2.1 ppm). A similar ratio was obtained when these compounds were applied topically to female adults. The relative potency of these enantiomers correlated well with the anti-cholinesterase activity of their respective oxidative enantiomers, (R)(+)-and (S)(-)-salioxon, which are assumed to have been formed after their application to the insects.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalAgricultural and Biological Chemistry
Volume53
Issue number1
DOIs
Publication statusPublished - Jan 1 1989

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Enantiomers
enantiomers
Bioactivity
bioactive properties
Cholinesterase Inhibitors
cholinesterase
Diptera
Larva
Insects
lethal concentration 50
Musca domestica
salioxon
salithion
oxidation
Oxidation
insects
larvae

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Biological activity of optically active salithion and salioxon. / Hirashima, Akinori; Ishaaya, Isaac; Ueno, Ryohei; Ichiyama, Yoshifumi; Wu, Shao Yong; Eto, Morifusa.

In: Agricultural and Biological Chemistry, Vol. 53, No. 1, 01.01.1989, p. 175-178.

Research output: Contribution to journalArticle

Hirashima, Akinori ; Ishaaya, Isaac ; Ueno, Ryohei ; Ichiyama, Yoshifumi ; Wu, Shao Yong ; Eto, Morifusa. / Biological activity of optically active salithion and salioxon. In: Agricultural and Biological Chemistry. 1989 ; Vol. 53, No. 1. pp. 175-178.
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