TY - JOUR
T1 - Biological activity of optically active salithion and salioxon
AU - Hirashima, Akinori
AU - Ishaaya, Isaac
AU - Ueno, Ryohei
AU - Ichiyama, Yoshifumi
AU - Wu, Shao Yong
AU - Eto, Morifusa
N1 - Funding Information:
Acknowledgments. This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan. We thank Kazuhiko Oyama and Ryuko Takeya in this laboratory for their skillful technical assistance.
PY - 1989/1
Y1 - 1989/1
N2 - Salioxon enantiomers were obtained from salithion enantiomers by MCPBA oxidation. The larvicidal and adulticidal activities of salithion enantiomers, and the anti-cholinesterase activity of salioxon enantiomers were determined on house flies. On larvae, the potency of (S)(-)-salithion (LC50 = 1.1 ppm) was about two-fold higher than the (R)(+)-enantiomer (LC50 = 2.1 ppm). A similar ratio was obtained when these compounds were applied topically to female adults. The relative potency of these enantiomers correlated well with the anti-cholinesterase activity of their respective oxidative enantiomers, (R)(+)-and (S)(-)-salioxon, which are assumed to have been formed after their application to the insects.
AB - Salioxon enantiomers were obtained from salithion enantiomers by MCPBA oxidation. The larvicidal and adulticidal activities of salithion enantiomers, and the anti-cholinesterase activity of salioxon enantiomers were determined on house flies. On larvae, the potency of (S)(-)-salithion (LC50 = 1.1 ppm) was about two-fold higher than the (R)(+)-enantiomer (LC50 = 2.1 ppm). A similar ratio was obtained when these compounds were applied topically to female adults. The relative potency of these enantiomers correlated well with the anti-cholinesterase activity of their respective oxidative enantiomers, (R)(+)-and (S)(-)-salioxon, which are assumed to have been formed after their application to the insects.
UR - http://www.scopus.com/inward/record.url?scp=0040931057&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0040931057&partnerID=8YFLogxK
U2 - 10.1080/00021369.1989.10869279
DO - 10.1080/00021369.1989.10869279
M3 - Article
AN - SCOPUS:0040931057
SN - 0916-8451
VL - 53
SP - 175
EP - 178
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 1
ER -