Biological features determining the chemosensitivity of gastric cancer

Y. Ichiyoshi, K. Endo, M. Yamamoto, Yoshihiko Maehara, K. Sugimachi

Research output: Contribution to journalReview article

Abstract

We analysed the relationship between several biological properties of gastric cancers and their chemosensitivity determined by MTT assay. Higher chemosensitivity was associated with poor differentiation, aneuploidy, and higher proliferative activity. Lymph node metastasis was more chemosensitive than primary lesion, while liver metastasis was less. Gastric cancer expressing multidrug-resistance associated protein (MRP) showed lower sensitivity to several anticancer drugs, including adriamycin and etoposide. p53 status and susceptibility to apoptosis were also associated with chemosensitivity. Thus, chemosensitivity of clinical gastric cancer might be increased if these characters can be modified by some new biologic therapy.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalHuman cell : official journal of Human Cell Research Society
Volume8
Issue number4
Publication statusPublished - Jan 1 1995

Fingerprint

Stomach Neoplasms
Neoplasm Metastasis
Multidrug Resistance-Associated Proteins
Biological Therapy
Aneuploidy
Etoposide
Doxorubicin
Lymph Nodes
Apoptosis
Liver
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Cell Biology
  • Cancer Research

Cite this

Ichiyoshi, Y., Endo, K., Yamamoto, M., Maehara, Y., & Sugimachi, K. (1995). Biological features determining the chemosensitivity of gastric cancer. Human cell : official journal of Human Cell Research Society, 8(4), 157-161.

Biological features determining the chemosensitivity of gastric cancer. / Ichiyoshi, Y.; Endo, K.; Yamamoto, M.; Maehara, Yoshihiko; Sugimachi, K.

In: Human cell : official journal of Human Cell Research Society, Vol. 8, No. 4, 01.01.1995, p. 157-161.

Research output: Contribution to journalReview article

Ichiyoshi, Y, Endo, K, Yamamoto, M, Maehara, Y & Sugimachi, K 1995, 'Biological features determining the chemosensitivity of gastric cancer', Human cell : official journal of Human Cell Research Society, vol. 8, no. 4, pp. 157-161.
Ichiyoshi, Y. ; Endo, K. ; Yamamoto, M. ; Maehara, Yoshihiko ; Sugimachi, K. / Biological features determining the chemosensitivity of gastric cancer. In: Human cell : official journal of Human Cell Research Society. 1995 ; Vol. 8, No. 4. pp. 157-161.
@article{5d338f57b4944e2a9fc7072fca45c3eb,
title = "Biological features determining the chemosensitivity of gastric cancer",
abstract = "We analysed the relationship between several biological properties of gastric cancers and their chemosensitivity determined by MTT assay. Higher chemosensitivity was associated with poor differentiation, aneuploidy, and higher proliferative activity. Lymph node metastasis was more chemosensitive than primary lesion, while liver metastasis was less. Gastric cancer expressing multidrug-resistance associated protein (MRP) showed lower sensitivity to several anticancer drugs, including adriamycin and etoposide. p53 status and susceptibility to apoptosis were also associated with chemosensitivity. Thus, chemosensitivity of clinical gastric cancer might be increased if these characters can be modified by some new biologic therapy.",
author = "Y. Ichiyoshi and K. Endo and M. Yamamoto and Yoshihiko Maehara and K. Sugimachi",
year = "1995",
month = "1",
day = "1",
language = "English",
volume = "8",
pages = "157--161",
journal = "Human Cell",
issn = "0914-7470",
publisher = "Springer Heidelberg",
number = "4",

}

TY - JOUR

T1 - Biological features determining the chemosensitivity of gastric cancer

AU - Ichiyoshi, Y.

AU - Endo, K.

AU - Yamamoto, M.

AU - Maehara, Yoshihiko

AU - Sugimachi, K.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - We analysed the relationship between several biological properties of gastric cancers and their chemosensitivity determined by MTT assay. Higher chemosensitivity was associated with poor differentiation, aneuploidy, and higher proliferative activity. Lymph node metastasis was more chemosensitive than primary lesion, while liver metastasis was less. Gastric cancer expressing multidrug-resistance associated protein (MRP) showed lower sensitivity to several anticancer drugs, including adriamycin and etoposide. p53 status and susceptibility to apoptosis were also associated with chemosensitivity. Thus, chemosensitivity of clinical gastric cancer might be increased if these characters can be modified by some new biologic therapy.

AB - We analysed the relationship between several biological properties of gastric cancers and their chemosensitivity determined by MTT assay. Higher chemosensitivity was associated with poor differentiation, aneuploidy, and higher proliferative activity. Lymph node metastasis was more chemosensitive than primary lesion, while liver metastasis was less. Gastric cancer expressing multidrug-resistance associated protein (MRP) showed lower sensitivity to several anticancer drugs, including adriamycin and etoposide. p53 status and susceptibility to apoptosis were also associated with chemosensitivity. Thus, chemosensitivity of clinical gastric cancer might be increased if these characters can be modified by some new biologic therapy.

UR - http://www.scopus.com/inward/record.url?scp=0029443992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029443992&partnerID=8YFLogxK

M3 - Review article

C2 - 8721085

AN - SCOPUS:0029443992

VL - 8

SP - 157

EP - 161

JO - Human Cell

JF - Human Cell

SN - 0914-7470

IS - 4

ER -