Biological immunoassay utilizing magnetic marker and high Tc superconducting quantum interference device magnetometer

Keiji Enpuku, Daisuke Kuroda, Akihiro Ohba, Tong Qing Yang, Kohji Yoshinaga, Tae Nakahara, Hiroyuki Kuma, Naotaka Hamasaki

Research output: Contribution to journalLetter

39 Citations (Scopus)

Abstract

Detection of the biological binding-reaction between an antigen and its antibody was performed by using a magnetic marker and a high Tc superconducting quantum interference device (SQUID) magnetometer. In this method, the binding reaction is detected by measuring the magnetic field from the marker. A new marker made of Fe3O4 particle with diameter of 25 nm was developed, and the remanent field of the marker was used for the detection of the antigen called Interleukin 8 (IL8). It was shown that the present system can detect 0.1 pg weight of IL8.

Original languageEnglish
Pages (from-to)L1436-L1438
JournalJapanese Journal of Applied Physics, Part 2: Letters
Volume42
Issue number12 A
DOIs
Publication statusPublished - Dec 1 2003

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Physics and Astronomy (miscellaneous)
  • Physics and Astronomy(all)

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