Biological implications of macrophage infiltration in human tumor angiogenesis

Mayumi Ono, Hitoe Torisu, Jun-Ichi Fukushi, Akihiro Nishie, Michihiko Kuwano

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Tumor angiogenesis is believed to be induced by increased production of angiogenic factors and decreased production of angiogenic inhibitors by cancer cells, vascular endothelial cells, and other stromal cell types. Most solid tumor cells are surrounded by stroma comprising interstitial connective tissue, blood vessels, fibroblastic cells, etc. Interaction between the stroma and malignant cells appears to have a critical role in the development of tumor neovasculature. We focused on macrophages, which demonstrate wide heterogeneity in biological function and have an essential role in tumor angiogenesis. Macrophages are terminally differentiated cells which produce a number of potent angiogenic cytokines and growth factors such as vascular endothelial growth factor, tumor necrosis factor-alpha, interleukin-8, and basic fibroblast growth factor. They also modulate events in the extracellular matrix through the secretion of extracellular matrix-degrading enzymes and -modulating enzymes. Thus macrophages could influence various stages of angiogenesis either positively or negatively. We found a close correlation between increased macrophage index, malignancy, and high vascular grade in malignant melanoma, and present a model for the possible involvement of activated macrophages in neovascularization in human malignant melanoma.

Original languageEnglish
JournalCancer Chemotherapy and Pharmacology, Supplement
Volume43
Publication statusPublished - Jun 5 1999

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Macrophages
Neoplasms
Angiogenesis Inducing Agents
Extracellular Matrix
Blood Vessels
Melanoma
Angiogenesis Inhibitors
Fibroblast Growth Factor 2
Enzymes
Stromal Cells
Interleukin-8
Connective Tissue
Vascular Endothelial Growth Factor A
Intercellular Signaling Peptides and Proteins
Endothelial Cells
Tumor Necrosis Factor-alpha
Cytokines

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pharmacology
  • Cancer Research

Cite this

Biological implications of macrophage infiltration in human tumor angiogenesis. / Ono, Mayumi; Torisu, Hitoe; Fukushi, Jun-Ichi; Nishie, Akihiro; Kuwano, Michihiko.

In: Cancer Chemotherapy and Pharmacology, Supplement, Vol. 43, 05.06.1999.

Research output: Contribution to journalArticle

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