Biological significance of the maximum standardized uptake values on positron emission tomography in non-small cell lung cancer

Tomoyoshi Takenaka, Tokujiro Yano, Kensaku Ito, Yousuke Morodomi, Naoko Miura, Daigo Kawano, Fumihiro Shoji, Koichiro Abe, Hiroshi Honda, Yoshihiko Maehara

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14 Citations (Scopus)

Abstract

Background: The 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) has recently become an important non-invasive tool for the diagnosis and staging in several cancers. The standardized uptake value (SUV) of primary tumor has been reported to relate to cancer progression and prognosis, however, biological mechanism is still unclear. Method: Seventy-nine patients with non-small cell lung cancer (NSCLC) who had undergone preoperative FDG-PET and a surgical resection were enrolled in this study. NSCLC tissue samples prepared from the surgical specimens were subjected to an immunohistochemical analysis for the expression of Ki-67 and vascular endothelial growth factor (VEGF) proteins. The relationships between the expression status of these proteins and SUVmax of primary tumors were evaluated. Result: Concerning the relationship with various clinicopathological findings, SUVmax of primary tumors was associated with histology, tumor proliferation, pleural or vascular invasion, and pathological stage. A significant correlation was observed between the SUVmax and either the Ki-67 or VEGF expression (P<0.001, P=0.006), respectively. Cases with both Ki-67-negative and VEGF-negative findings exhibited a significantly lower SUVmax than those with single positive or double positive cases (P=0.006, P<0.001). Conclusion: The SUVmax was associated with the expression of Ki-67 and VEGF in NSCLC. These findings indicated that the SUVmax of primary tumors might therefore reflect the biological malignant potential in NSCLC.

Original languageEnglish
Pages (from-to)688-692
Number of pages5
JournalJournal of Surgical Oncology
Volume100
Issue number8
DOIs
Publication statusPublished - Dec 15 2009

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Non-Small Cell Lung Carcinoma
Positron-Emission Tomography
Vascular Endothelial Growth Factor A
Neoplasms
Fluorodeoxyglucose F18
Deoxyglucose
Blood Vessels
Histology
Proteins

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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Biological significance of the maximum standardized uptake values on positron emission tomography in non-small cell lung cancer. / Takenaka, Tomoyoshi; Yano, Tokujiro; Ito, Kensaku; Morodomi, Yousuke; Miura, Naoko; Kawano, Daigo; Shoji, Fumihiro; Abe, Koichiro; Honda, Hiroshi; Maehara, Yoshihiko.

In: Journal of Surgical Oncology, Vol. 100, No. 8, 15.12.2009, p. 688-692.

Research output: Contribution to journalArticle

Takenaka, T, Yano, T, Ito, K, Morodomi, Y, Miura, N, Kawano, D, Shoji, F, Abe, K, Honda, H & Maehara, Y 2009, 'Biological significance of the maximum standardized uptake values on positron emission tomography in non-small cell lung cancer', Journal of Surgical Oncology, vol. 100, no. 8, pp. 688-692. https://doi.org/10.1002/jso.21386
Takenaka, Tomoyoshi ; Yano, Tokujiro ; Ito, Kensaku ; Morodomi, Yousuke ; Miura, Naoko ; Kawano, Daigo ; Shoji, Fumihiro ; Abe, Koichiro ; Honda, Hiroshi ; Maehara, Yoshihiko. / Biological significance of the maximum standardized uptake values on positron emission tomography in non-small cell lung cancer. In: Journal of Surgical Oncology. 2009 ; Vol. 100, No. 8. pp. 688-692.
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