Biologically active glycosides from asteroidea, 42. Isolation and structure of a new biologically active ganglioside molecular species from the starfish Asterina pectinifera

Ryuichi Higuchi, Shinichi Inoue, Kouji Inagaki, Maki Sakai, Tomofumi Miyamoto, Tetsuya Komori, Masanori Inagaki, Ryuichi Isobe

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A ganglioside molecular species GP-3 (1) has been obtained from the water-soluble lipid fraction of the chloroform/methanol extract of the starfish Asterina pectinifera. The structure of the ganglioside has been determined on the basis of chemical and spectroscopic evidence. Compound 1 represents new ganglioside molecular species possessing two moles of sialic acids at the inner part of the sugar moiety. Partial hydrolysis by hot water and an enzymatic hydrolysis by means of endoglycoceramidase (EGCase) have proved useful for structure elucidation of the complex oligosaccharide moiety. Moreover, 1 exhibits neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cells, in the presence of nerve growth factor (NGF).

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume54
Issue number3
DOIs
Publication statusPublished - Mar 1 2006

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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