Biologically active glycosides from asteroidea, 43. Isolation and structure of a new neuritogenic-active ganglioside molecular species from the starfish Linckia laevigata

Masanori Inagaki, Tomofumi Miyamoto, Ryuichi Isobe, Ryuichi Higuchi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A ganglioside molecular species, LLG-5 (1), has been obtained from the water soluble lipid fraction of the CHCl3/MeOH extract of the starfish Linckia laevigata. On the basis of chemical and spectroscopic findings, the structure of 1 has been elucidated. Negative ion FAB-MS provided important information both on the structure of the sugar moiety and on the molecular mass of the ganglioside. 1 is a new ganglioside molecular species possessing a 2→11 linked linear-type trisialosyl moiety. Moreover, 1 exhibited neuritogenic activity in rat pheochromocytoma PC-12 cells in the presence of nerve growth factor.

Original languageEnglish
Pages (from-to)1551-1554
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume53
Issue number12
DOIs
Publication statusPublished - Dec 2005

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Fingerprint Dive into the research topics of 'Biologically active glycosides from asteroidea, 43. Isolation and structure of a new neuritogenic-active ganglioside molecular species from the starfish Linckia laevigata'. Together they form a unique fingerprint.

  • Cite this