Biologically selective potassium channel openers having 1,1- diethylpropyl group

Kazuya Yoshiizumi, Norihiko Seko, Noriyasu Nishimura, Shoji Ikeda, Kohichiro Yoshino, Hirosato Kondo, Kazutaka Tanizawa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.

Original languageEnglish
Pages (from-to)3397-3402
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number23
DOIs
Publication statusPublished - Dec 1 1998
Externally publishedYes

Fingerprint

Potassium Channels
Structure-Activity Relationship
Antihypertensive Agents
Derivatives

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Biologically selective potassium channel openers having 1,1- diethylpropyl group. / Yoshiizumi, Kazuya; Seko, Norihiko; Nishimura, Noriyasu; Ikeda, Shoji; Yoshino, Kohichiro; Kondo, Hirosato; Tanizawa, Kazutaka.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 8, No. 23, 01.12.1998, p. 3397-3402.

Research output: Contribution to journalArticle

Yoshiizumi, Kazuya ; Seko, Norihiko ; Nishimura, Noriyasu ; Ikeda, Shoji ; Yoshino, Kohichiro ; Kondo, Hirosato ; Tanizawa, Kazutaka. / Biologically selective potassium channel openers having 1,1- diethylpropyl group. In: Bioorganic and Medicinal Chemistry Letters. 1998 ; Vol. 8, No. 23. pp. 3397-3402.
@article{64cb9b6c8e2644a9afd1b548c7568c7a,
title = "Biologically selective potassium channel openers having 1,1- diethylpropyl group",
abstract = "To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.",
author = "Kazuya Yoshiizumi and Norihiko Seko and Noriyasu Nishimura and Shoji Ikeda and Kohichiro Yoshino and Hirosato Kondo and Kazutaka Tanizawa",
year = "1998",
month = "12",
day = "1",
doi = "10.1016/S0960-894X(98)00625-8",
language = "English",
volume = "8",
pages = "3397--3402",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "23",

}

TY - JOUR

T1 - Biologically selective potassium channel openers having 1,1- diethylpropyl group

AU - Yoshiizumi, Kazuya

AU - Seko, Norihiko

AU - Nishimura, Noriyasu

AU - Ikeda, Shoji

AU - Yoshino, Kohichiro

AU - Kondo, Hirosato

AU - Tanizawa, Kazutaka

PY - 1998/12/1

Y1 - 1998/12/1

N2 - To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.

AB - To find out selective potassium channel openers (PCOs), we synthesized several 3,5-disubstituted phenylcyanoguanidine derivatives and investigated their structure-activity relationships (SAR). As a result, we discovered selective PCOs having 1,1-diethylpropyl group toward antihypertensive activity.

UR - http://www.scopus.com/inward/record.url?scp=0032401163&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032401163&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(98)00625-8

DO - 10.1016/S0960-894X(98)00625-8

M3 - Article

C2 - 9873741

AN - SCOPUS:0032401163

VL - 8

SP - 3397

EP - 3402

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 23

ER -