Biomimetic synthesis of α-amino acids from α-keto acids

Seiji Shinkai, Hisatake Hamada, Akihiko Dohyama, Osamu Manabe

Research output: Contribution to journalArticle

14 Citations (Scopus)


Protonated α-imino acids, RC(=NH2+)COOH, were easily reduced to α-amino acids by an acid-stable NADH analogue, 1-benzyl-3-carbamoyl-1,4-dihydroquinoline. This is the first model reaction of NADH-mediated α-amino acid synthesis from α-keto acids.

Original languageEnglish
Pages (from-to)1661-1664
Number of pages4
JournalTetrahedron Letters
Issue number17
Publication statusPublished - Jan 1 1980
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Shinkai, S., Hamada, H., Dohyama, A., & Manabe, O. (1980). Biomimetic synthesis of α-amino acids from α-keto acids. Tetrahedron Letters, 21(17), 1661-1664.