Biosynthetic mechanism for L-gulose in main polar lipids of thermoplasma acidophilum and possible resemblance to plant ascorbic acid biosynthesis

Noriaki Yamauchi, Yusuke Nakayama

Research output: Contribution to journalArticle

Abstract

L-Gulose is a very rare sugar, but appears as a sugar component of the main polar lipids characteristic in such a thermophilic archaeon as Thermoplasma acidophilum that lives without cell walls in a highly acidic environment. The biosynthesis of L-gulose in this thermophilic organism was investigated with deuterium- labeling experiments. L-Gulose was found to be biosynthesized from D-glucose via stepwise stereochemical inversion at C-2 and C-5. The involvement of an epimerase related to GDP-mannose 3,5-epimerase, the key enzyme of plant ascorbate biosynthesis, was also suggested in this C-5 inversion. The resemblance of Lgulose biosynthesis in archaea and plants might be suggested from these results.

Original languageEnglish
Pages (from-to)2087-2093
Number of pages7
JournalBioscience, Biotechnology and Biochemistry
Volume77
Issue number10
DOIs
Publication statusPublished - Nov 4 2013

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biotechnology
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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