複数回膜貫通型膜タンパク質の立体構造形成機構: バンド3タンパク質研究の成果より

Translated title of the contribution: Biosynthetic Mechanism of Polytopic Membrane Protein as Deduced by Study of Band 3 Protein

阿部 義人, 濱崎 直孝

Research output: Contribution to journalArticle

Abstract

The conventional view of biosynthesis of membrane-embedded regions of integral membrane proteins is that the topology of membrane proteins is determined by signal-anchor sequences and signal-anchor sequence of type II. Here, we briefly review the evidence that in the case of integral membrane proteins with many membrane spans, and that the topology of membrane proteins is determined not only by signal-anchor sequences and signal-anchor sequence of type II, but also by signal-anchor sequence of type I. Evidence from band 3 study indicates that hydrophobic membrane peptide portions are not necessarily in contact with lipids in the membrane lipid bilayer and that even hydrophilic peptide portions are integrated into the lipid bilyar by the action of signal-anchor sequence of type I.
Translated title of the contributionBiosynthetic Mechanism of Polytopic Membrane Protein as Deduced by Study of Band 3 Protein
Original languageJapanese
Pages (from-to)4-9
Number of pages6
JournalBiophysics (Japan)
Volume46
Issue number1
Publication statusPublished - Jan 25 2006

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