Biosynthetic regulation and intracellular transport of phosphatidylserine in mammalian cells

Osamu Kuge, Masahiro Nishijima

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

In mammalian cells, phosphatidylserine (PtdSer) is synthesized through the action of the endoplasmic reticulum enzymes, PtdSer synthase 1 and 2, and the decarboxylation of PtdSer accounts for the majority of phosphatidylethanolamine (PtdEtn) synthesis. PtdSer decarboxylation for PtdEtn formation occurs in the mitochondria. In addition, the transport of PtdSer from the endoplasmic reticulum to the mitochondria is probably a rate limiting step for PtdEtn synthesis through the decarboxylation pathway. Therefore, the regulation of PtdSer synthesis and its intracellular transport appear to be essential events for the maintenance of normal cellular PtdSer and PtdEtn levels. Here we describe the current understanding of the regulation of PtdSer biosynthesis and the transport of PtdSer from the ER to the mitochondria in mammalian cells.

Original languageEnglish
Pages (from-to)397-403
Number of pages7
JournalJournal of Biochemistry
Volume133
Issue number4
DOIs
Publication statusPublished - Apr 1 2003
Externally publishedYes

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Phosphatidylserines
Cells
Decarboxylation
Mitochondria
Endoplasmic Reticulum
CDPdiacylglycerol-Serine O-Phosphatidyltransferase
Biosynthesis
Maintenance
phosphatidylethanolamine
Enzymes

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

Biosynthetic regulation and intracellular transport of phosphatidylserine in mammalian cells. / Kuge, Osamu; Nishijima, Masahiro.

In: Journal of Biochemistry, Vol. 133, No. 4, 01.04.2003, p. 397-403.

Research output: Contribution to journalReview article

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