Biosynthetic studies of the tetramic acid antibiotic trichosetin

Eufrocinio C. Marfori; Takeshi Bamba; Shin Ichiro Kajiyama; Ei Ichiro Fukusaki; Akio Kobayashi

doi:10.1016/S0040-4020(02)00689-0

Biosynthetic studies of the tetramic acid antibiotic trichosetin

Eufrocinio C. Marfori, Takeshi Bamba, Shin Ichiro Kajiyama, Ei Ichiro Fukusaki, Akio Kobayashi

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A feeding experiment with ¹³C-labeled precursors was conducted in the dual cultures of Trichoderma harzianum H14 and Catharanthus roseus callus to determine the biosynthetic origin of the carbon atoms in trichosetin. Results showed that trichosetin originated from two separate biogenetic units. One unit is an octaketide intermediate directly derived from eight intact acetate units joined in a head-to-tail fashion of a polyketide pathway. The other unit is serine.

Original language	English
Pages (from-to)	6655-6658
Number of pages	4
Journal	Tetrahedron
Volume	58
Issue number	33
DOIs	https://doi.org/10.1016/S0040-4020(02)00689-0
Publication status	Published - Aug 12 2002
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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abstract = "A feeding experiment with 13C-labeled precursors was conducted in the dual cultures of Trichoderma harzianum H14 and Catharanthus roseus callus to determine the biosynthetic origin of the carbon atoms in trichosetin. Results showed that trichosetin originated from two separate biogenetic units. One unit is an octaketide intermediate directly derived from eight intact acetate units joined in a head-to-tail fashion of a polyketide pathway. The other unit is serine.",

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AU - Bamba, Takeshi

AU - Kajiyama, Shin Ichiro

AU - Fukusaki, Ei Ichiro

AU - Kobayashi, Akio

PY - 2002/8/12

Y1 - 2002/8/12

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AB - A feeding experiment with 13C-labeled precursors was conducted in the dual cultures of Trichoderma harzianum H14 and Catharanthus roseus callus to determine the biosynthetic origin of the carbon atoms in trichosetin. Results showed that trichosetin originated from two separate biogenetic units. One unit is an octaketide intermediate directly derived from eight intact acetate units joined in a head-to-tail fashion of a polyketide pathway. The other unit is serine.

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JO - Tetrahedron

JF - Tetrahedron

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ER -

Biosynthetic studies of the tetramic acid antibiotic trichosetin

Abstract

All Science Journal Classification (ASJC) codes

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