Biotransformation of Khellin to Khellol by Aspergillus niger and the evaluation of their biological activities

Ahmed Ashour, Saleh El-Sharkawy, Mohamed Amer, Fatma Abdel Bar, Amira Mera, Toshiro Nagata, Ryuichiro Kondo, Kuniyoshi Shimizu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Biotransformation of khellin using Aspergillus niger ATCC 10549 resulted in the production of khellol. The biological activities of the transformed product and khellin were established by antioxidant and acetylcholine esterase inhibitory assays. Khellol exhibited a higher degree of antioxidant and acetylcholine esterase inhibitory activities compared to khellin. This is the first report on the biotransformation of khellin by microorganisms and the first evaluation of the neuroprotective activity of either khellin or khellol.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalOpen Bioactive Compounds Journal
Volume4
DOIs
Publication statusPublished - Jan 1 2013

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Pharmaceutical Science
  • Molecular Medicine
  • Molecular Biology
  • Biochemistry
  • Pharmacology

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