Biphasic alteration in the trigeminal nociceptive neuronal responses after intracerebroventricular injection of prostaglandin E2 in rats

Takakazu Oka, Masako Hosoi, Kae Oka, Tetsuro Hori

Research output: Contribution to journalArticle

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Abstract

To investigate the role of prostaglandin E2 (PGE2) in the brain in nociception electrophysiologically, we injected PGE2 (0.1 fmol-1 nmol) into the lateral cerebroventricle (LCV) of anesthetized rats and observed the changes of the responses of the wide dynamic range (WDR) neurons in the trigeminal nucleus caudalis to noxious pinching of facial skin. The LCV injection of PGE2 at 1 fmol and 10 fmol enhanced the responses of the majority of WDR neurons to noxious stimuli, whereas that of PGE2 at 100 pmol and 1 nmol suppressed them. The enhancement and suppression of the nociceptive responses of WDR neurons were observed 15-25 min and 5-15 min after injection of PGE2 at 10 fmol (3.53 pg) and 1 nmol (353 ng), respectively. On the other hand, the LCV injection of PGE2 at both 10 fmol and 1 nmol had no effect on the responses of the low threshold mechanoreceptive neurons to skin brushing. These results provide electrophysiological evidence that brain-derived PGE2 has biphasic effects on nociception, i.e., it induces mechanical hyperalgesia at lower doses and hypoalgesia at higher doses in rats.

Original languageEnglish
Pages (from-to)354-357
Number of pages4
JournalBrain Research
Volume749
Issue number2
DOIs
Publication statusPublished - Feb 28 1997

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Dinoprostone
Injections
Neurons
Nociception
Trigeminal Nuclei
Skin
Hyperalgesia
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Biphasic alteration in the trigeminal nociceptive neuronal responses after intracerebroventricular injection of prostaglandin E2 in rats. / Oka, Takakazu; Hosoi, Masako; Oka, Kae; Hori, Tetsuro.

In: Brain Research, Vol. 749, No. 2, 28.02.1997, p. 354-357.

Research output: Contribution to journalArticle

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