Bisphenol A diglycidyl ether (BADGE) suppresses tumor necrosis factor-α production as a PPARγ agonist in the murine macrophage-like cell line, RAW 264.7

Makoto Nakamuta, Munechika Enjoji, Koutaro Uchimura, Satoshi Ohta, Rie Sugimoto, Kazuhiro Kotoh, Masaki Kato, Takashi Irie, Tatsushi Muta, Hajime Nawata

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27 Citations (Scopus)

Abstract

Bisphenol A diglycidyl ether (BADGE) is a newly described peroxisome proliferator-activated receptor γ (PPARγ) antagonist in adipogenic cells. In contrast, in the macrophage-like cell line RAW 264.7, BADGE, like the PPARγ agonist pioglitazone hydrochloride, not only increased promoter activity of the PPARγ-luciferase reporter gene, but also suppressed lipopolysaccharide (LPS)-induced tumor necrosis factor-α (TNF-α) production. These results suggest that BADGE is a PPARγ agonist in RAW 264.7 cells. Furthermore, overexpression of the coactivator p300 restored BADGE- or pioglitazone hydrochloride-suppressed promoter activity of the nuclear factor-kappa B (NF-κB)-luciferase reporter gene, suggesting that PPARγ may interfere with NF-κB transcriptional activity via coactivator competition.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
JournalCell Biology International
Volume26
Issue number3
DOIs
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Cell Biology

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    Nakamuta, M., Enjoji, M., Uchimura, K., Ohta, S., Sugimoto, R., Kotoh, K., Kato, M., Irie, T., Muta, T., & Nawata, H. (2002). Bisphenol A diglycidyl ether (BADGE) suppresses tumor necrosis factor-α production as a PPARγ agonist in the murine macrophage-like cell line, RAW 264.7. Cell Biology International, 26(3), 235-241. https://doi.org/10.1006/cbir.2001.0838