Bizarre parosteal osteochondromatous proliferation with a t(1;17) translocation

Makoto Endo, Tadashi Hasegawa, Takashi Tashiro, Umio Yamaguchi, Yuki Morimoto, Fumihiko Nakatani, Tadakazu Shimoda

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Bizarre parosteal osteochondromatous proliferation (BPOP) is a benign lesion that tends to recur repeatedly. Histologically, BPOP contains three components (cartilage, bone, and spindle cells) in differing amounts. The histological findings of BPOP are similar to those of florid reactive periostitis (FRP) and subungual (Dupuytren's) exostosis. Some authors have postulated that all of these conditions are reactive proliferative lesions representing different phases of reactive processes. Whether BPOP is a reactive proliferative lesion or a neoplastic lesion, however, remains controversial. Recently, a t(1;17)(q32;q21) translocation in BPOP was detected using chromosome banding and fluorescence in situ hybridization (FISH) analyses. Here, we describe a 39-year-old Japanese female with BPOP arising in the proximal phalanx of her third toe. A cytogenetic analysis revealed a t(1;17)(q42;q23) translocation. The breakpoints in this case are located close to those of previously reported cases. These results suggest that t(1;17) is a distinct translocation of BPOP and that BPOP is a neoplastic lesion, rather than a reactive proliferative process.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalVirchows Archiv
Volume447
Issue number1
DOIs
Publication statusPublished - Jul 1 2005
Externally publishedYes

Fingerprint

Toe Phalanges
Periostitis
Chromosome Banding
Cytogenetic Analysis
Fluorescence In Situ Hybridization
Cartilage
Bone and Bones
Subungual exostoses

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Endo, M., Hasegawa, T., Tashiro, T., Yamaguchi, U., Morimoto, Y., Nakatani, F., & Shimoda, T. (2005). Bizarre parosteal osteochondromatous proliferation with a t(1;17) translocation. Virchows Archiv, 447(1), 99-102. https://doi.org/10.1007/s00428-005-1266-7

Bizarre parosteal osteochondromatous proliferation with a t(1;17) translocation. / Endo, Makoto; Hasegawa, Tadashi; Tashiro, Takashi; Yamaguchi, Umio; Morimoto, Yuki; Nakatani, Fumihiko; Shimoda, Tadakazu.

In: Virchows Archiv, Vol. 447, No. 1, 01.07.2005, p. 99-102.

Research output: Contribution to journalArticle

Endo, M, Hasegawa, T, Tashiro, T, Yamaguchi, U, Morimoto, Y, Nakatani, F & Shimoda, T 2005, 'Bizarre parosteal osteochondromatous proliferation with a t(1;17) translocation', Virchows Archiv, vol. 447, no. 1, pp. 99-102. https://doi.org/10.1007/s00428-005-1266-7
Endo M, Hasegawa T, Tashiro T, Yamaguchi U, Morimoto Y, Nakatani F et al. Bizarre parosteal osteochondromatous proliferation with a t(1;17) translocation. Virchows Archiv. 2005 Jul 1;447(1):99-102. https://doi.org/10.1007/s00428-005-1266-7
Endo, Makoto ; Hasegawa, Tadashi ; Tashiro, Takashi ; Yamaguchi, Umio ; Morimoto, Yuki ; Nakatani, Fumihiko ; Shimoda, Tadakazu. / Bizarre parosteal osteochondromatous proliferation with a t(1;17) translocation. In: Virchows Archiv. 2005 ; Vol. 447, No. 1. pp. 99-102.
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