Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus

S. Sakuda, M. Ono, H. Ikeda, T. Nakamura, Y. Inagaki, R. Kawachi, J. Nakayama, A. Suzuki, A. Isogai, H. Nagasawa

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Abstract

Blasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 μm.

Original languageEnglish
Pages (from-to)1265-1271
Number of pages7
JournalJournal of Antibiotics
Volume53
Issue number11
DOIs
Publication statusPublished - Jan 1 2000
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Sakuda, S., Ono, M., Ikeda, H., Nakamura, T., Inagaki, Y., Kawachi, R., ... Nagasawa, H. (2000). Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus. Journal of Antibiotics, 53(11), 1265-1271. https://doi.org/10.7164/antibiotics.53.1265