Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus

S. Sakuda, M. Ono, H. Ikeda, T. Nakamura, Y. Inagaki, R. Kawachi, Jiro Nakayama, A. Suzuki, A. Isogai, H. Nagasawa

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Blasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 μm.

Original languageEnglish
Pages (from-to)1265-1271
Number of pages7
JournalJournal of Antibiotics
Volume53
Issue number11
DOIs
Publication statusPublished - Jan 1 2000
Externally publishedYes

Fingerprint

Aflatoxins
Aspergillus
Anti-Bacterial Agents
blasticidin A
aflastatin A
tetramic acid

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Sakuda, S., Ono, M., Ikeda, H., Nakamura, T., Inagaki, Y., Kawachi, R., ... Nagasawa, H. (2000). Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus. Journal of Antibiotics, 53(11), 1265-1271. https://doi.org/10.7164/antibiotics.53.1265

Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus. / Sakuda, S.; Ono, M.; Ikeda, H.; Nakamura, T.; Inagaki, Y.; Kawachi, R.; Nakayama, Jiro; Suzuki, A.; Isogai, A.; Nagasawa, H.

In: Journal of Antibiotics, Vol. 53, No. 11, 01.01.2000, p. 1265-1271.

Research output: Contribution to journalArticle

Sakuda, S, Ono, M, Ikeda, H, Nakamura, T, Inagaki, Y, Kawachi, R, Nakayama, J, Suzuki, A, Isogai, A & Nagasawa, H 2000, 'Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus', Journal of Antibiotics, vol. 53, no. 11, pp. 1265-1271. https://doi.org/10.7164/antibiotics.53.1265
Sakuda S, Ono M, Ikeda H, Nakamura T, Inagaki Y, Kawachi R et al. Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus. Journal of Antibiotics. 2000 Jan 1;53(11):1265-1271. https://doi.org/10.7164/antibiotics.53.1265
Sakuda, S. ; Ono, M. ; Ikeda, H. ; Nakamura, T. ; Inagaki, Y. ; Kawachi, R. ; Nakayama, Jiro ; Suzuki, A. ; Isogai, A. ; Nagasawa, H. / Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus. In: Journal of Antibiotics. 2000 ; Vol. 53, No. 11. pp. 1265-1271.
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