Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus

S. Sakuda, M. Ono, H. Ikeda, T. Nakamura, Y. Inagaki, R. Kawachi, J. Nakayama, A. Suzuki, A. Isogai, H. Nagasawa

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Blasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 μm.

Original languageEnglish
Pages (from-to)1265-1271
Number of pages7
JournalJournal of Antibiotics
Volume53
Issue number11
DOIs
Publication statusPublished - 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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