TY - GEN
T1 - Blind spot of G1/S checkpoint
T2 - IASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008
AU - Iwamoto, Kazunari
AU - Tashima, Yoshihiko
AU - Hamada, Hiroyuki
AU - Okamoto, Masahiro
AU - Eguchi, Yukihiro
PY - 2008
Y1 - 2008
N2 - The transition from G1 phase to S phase in the cell cycle is regulated by G1/S checkpoint, which can arrest the G1 progression when DNA-damage occurred. However, it was reported that G1 arrest was not induced when DNA-damage occurred at late G1 phase. This finding implies that G1/S checkpoint cannot detect the DNA-damage on late G1 phase. The inadequate regulation of G1/S checkpoint to cell cycle progression produces serious effects on both the cellular homeostasis and genetic stability. In this paper, to verify the inadequate regulation of G1/S checkpoint, we constructed a novel mathematical model (proposed model), which integrated G1/S checkpoint with p53-dependent DNA-damage pathway, and simulated a dynamic behavior of G1/S transition involving DNA-damage. The hot issue of the study is that the simulation results of the proposed model with/without DNA-damage can qualitatively realize the biological findings such that G1/S checkpoint cannot detect the DNA-damage on late G1 phase.
AB - The transition from G1 phase to S phase in the cell cycle is regulated by G1/S checkpoint, which can arrest the G1 progression when DNA-damage occurred. However, it was reported that G1 arrest was not induced when DNA-damage occurred at late G1 phase. This finding implies that G1/S checkpoint cannot detect the DNA-damage on late G1 phase. The inadequate regulation of G1/S checkpoint to cell cycle progression produces serious effects on both the cellular homeostasis and genetic stability. In this paper, to verify the inadequate regulation of G1/S checkpoint, we constructed a novel mathematical model (proposed model), which integrated G1/S checkpoint with p53-dependent DNA-damage pathway, and simulated a dynamic behavior of G1/S transition involving DNA-damage. The hot issue of the study is that the simulation results of the proposed model with/without DNA-damage can qualitatively realize the biological findings such that G1/S checkpoint cannot detect the DNA-damage on late G1 phase.
UR - http://www.scopus.com/inward/record.url?scp=74549201024&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74549201024&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:74549201024
SN - 9780889867741
T3 - IASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008
SP - 241
EP - 246
BT - IASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008
Y2 - 16 November 2008 through 18 November 2008
ER -