Blind spot of G1/S checkpoint: G1/S checkpoint is invaded by DNA-damage after R-point

Kazunari Iwamoto, Yoshihiko Tashima, Hiroyuki Hamada, Masahiro Okamoto, Yukihiro Eguchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The transition from G1 phase to S phase in the cell cycle is regulated by G1/S checkpoint, which can arrest the G1 progression when DNA-damage occurred. However, it was reported that G1 arrest was not induced when DNA-damage occurred at late G1 phase. This finding implies that G1/S checkpoint cannot detect the DNA-damage on late G1 phase. The inadequate regulation of G1/S checkpoint to cell cycle progression produces serious effects on both the cellular homeostasis and genetic stability. In this paper, to verify the inadequate regulation of G1/S checkpoint, we constructed a novel mathematical model (proposed model), which integrated G1/S checkpoint with p53-dependent DNA-damage pathway, and simulated a dynamic behavior of G1/S transition involving DNA-damage. The hot issue of the study is that the simulation results of the proposed model with/without DNA-damage can qualitatively realize the biological findings such that G1/S checkpoint cannot detect the DNA-damage on late G1 phase.

Original languageEnglish
Title of host publicationIASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008
Pages241-246
Number of pages6
Publication statusPublished - 2008
EventIASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008 - Orlando, FL, United States
Duration: Nov 16 2008Nov 18 2008

Publication series

NameIASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008

Other

OtherIASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008
Country/TerritoryUnited States
CityOrlando, FL
Period11/16/0811/18/08

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Biomedical Engineering
  • Health Informatics

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