Blind spot of G1/S checkpoint: G1/S checkpoint is invaded by DNA-damage after R-point

Kazunari Iwamoto, Yoshihiko Tashima, Hiroyuki Hamada, Masahiro Okamoto, Yukihiro Eguchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The transition from G1 phase to S phase in the cell cycle is regulated by G1/S checkpoint, which can arrest the G1 progression when DNA-damage occurred. However, it was reported that G1 arrest was not induced when DNA-damage occurred at late G1 phase. This finding implies that G1/S checkpoint cannot detect the DNA-damage on late G1 phase. The inadequate regulation of G1/S checkpoint to cell cycle progression produces serious effects on both the cellular homeostasis and genetic stability. In this paper, to verify the inadequate regulation of G1/S checkpoint, we constructed a novel mathematical model (proposed model), which integrated G1/S checkpoint with p53-dependent DNA-damage pathway, and simulated a dynamic behavior of G1/S transition involving DNA-damage. The hot issue of the study is that the simulation results of the proposed model with/without DNA-damage can qualitatively realize the biological findings such that G1/S checkpoint cannot detect the DNA-damage on late G1 phase.

Original languageEnglish
Title of host publicationIASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008
Pages241-246
Number of pages6
Publication statusPublished - Dec 1 2008
EventIASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008 - Orlando, FL, United States
Duration: Nov 16 2008Nov 18 2008

Publication series

NameIASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008

Other

OtherIASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008
CountryUnited States
CityOrlando, FL
Period11/16/0811/18/08

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All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Biomedical Engineering
  • Health Informatics

Cite this

Iwamoto, K., Tashima, Y., Hamada, H., Okamoto, M., & Eguchi, Y. (2008). Blind spot of G1/S checkpoint: G1/S checkpoint is invaded by DNA-damage after R-point. In IASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008 (pp. 241-246). (IASTED International Symposium on Computational Biology and Bioinformatics, CBB 2008).