Blockade of androgen-induced malignant phenotypes by flutamide administration in human salivary duct carcinoma cells

Yu Kamata, Tomoki Sumida, Ryuichi Murase, Hiroyuki Nakano, Tomohiro Yamada, Yoshihide Mori

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background/Aim: Androgens are known to play a critical role in prostate cancer progression, but their effect on malignant phenotypes in salivary gland cancer is unclear. The androgen-androgen receptor (AR) axis may be involved in malignant phenotypes of salivary duct carcinoma (SDC) cells and therefore may be a new target for SDC treatment. To test this hypothesis, we investigated the effect of the androgen 5α-dihydrotestosterone (DHT) on proliferation, migration, and invasiveness of SDC cells. Materials and Methods: We used a wound-healing assay to measure cell migration and a Boyden chamber invasion assay to investigate SDC cell invasive capacity. Results: DHT treatment increased cell proliferation, migration, and invasion. However, treatment with flutamide, an AR inhibitor, blocked the effects of DHT. Conclusion: These results suggest that the androgen-AR axis is involved in SDC malignancy and may be an effective therapeutic target for treatment of human SDC.

Original languageEnglish
Pages (from-to)6071-6075
Number of pages5
JournalAnticancer research
Volume36
Issue number11
DOIs
Publication statusPublished - Nov 2016

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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