Blockade of morphine-induced place preference by diazepam in mice

Tsutomu Suzuki, Tsuda Makoto, Masahiko Funada, Miwa Misawa

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The effects of diazepam on morphine-induced place preference were examined in mice. Pretreatment with diazepam (2 mg/kg i.p.) 30 min prior to morphine injection significantly abolished the morphine (5 mg/kg s.c.)-induced place preference, and this effect of diazepam was antagonized by pretreatment with flumazenil. In addition, pretreatment with diazepam prevented the morphine (5 mg/kg s.c.)-induced increase in dopamine turnover in the limbic forebrain. These results suggest that pretreatment with diazepam may suppress the rewarding effects of morphine.

Original languageEnglish
Pages (from-to)327-330
Number of pages4
JournalEuropean Journal of Pharmacology
Volume280
Issue number3
DOIs
Publication statusPublished - Jul 14 1995
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Cellular and Molecular Neuroscience

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