Blood compatibility of organic-inorganic biomedical materials

Akiyoshi Osaka, Tomohiko Yoshioka, Takeshi Yabuta, Kanji Tsuru, Satoshi Hayakawa

Research output: Contribution to journalArticle

Abstract

Organic-inorganic hybrids involving Ti-O bonds were coated on stainless-steel (SUS316L) substrates. Tetraisopropoxide and titanium methacrylate triisopropoxide were employed as the major starting chemicals to provide TiO2-polydimethylsiloxane (PDMS) layers or organotitanium molecular thin layers, respectively. Fourier transform infrared spectra indicated that each layer contained Ti-O bonds in their structure. The obtained hybrid layers had little effects on the blood-clotting times such as active partial thromboplastin time and pro thrombin time. In addition, the number of adhered platelet on the TiO2-PDMS layers depended on the composition, while the organotitanium molecular thin layers suppressed fibrinogen adsorption compared with coating-free SUS 316L substrate.

Original languageEnglish
Pages (from-to)713-716
Number of pages4
JournalKey Engineering Materials
Volume284-286
DOIs
Publication statusPublished - Jan 1 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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    Osaka, A., Yoshioka, T., Yabuta, T., Tsuru, K., & Hayakawa, S. (2005). Blood compatibility of organic-inorganic biomedical materials. Key Engineering Materials, 284-286, 713-716. https://doi.org/10.4028/0-87849-961-x.713