Blood compatibility of organic-inorganic biomedical materials

Akiyoshi Osaka, Tomohiko Yoshioka, Takeshi Yabuta, Kanji Tsuru, Satoshi Hayakawa

Research output: Contribution to journalArticle

Abstract

Organic-inorganic hybrids involving Ti-O bonds were coated on stainless-steel (SUS316L) substrates. Tetraisopropoxide and titanium methacrylate triisopropoxide were employed as the major starting chemicals to provide TiO2-polydimethylsiloxane (PDMS) layers or organotitanium molecular thin layers, respectively. Fourier transform infrared spectra indicated that each layer contained Ti-O bonds in their structure. The obtained hybrid layers had little effects on the blood-clotting times such as active partial thromboplastin time and pro thrombin time. In addition, the number of adhered platelet on the TiO2-PDMS layers depended on the composition, while the organotitanium molecular thin layers suppressed fibrinogen adsorption compared with coating-free SUS 316L substrate.

Original languageEnglish
Pages (from-to)713-716
Number of pages4
JournalKey Engineering Materials
Volume284-286
Publication statusPublished - Dec 1 2005

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Polydimethylsiloxane
Blood
Methacrylates
Stainless Steel
Thromboplastin
Substrates
Platelets
Thrombin
Fibrinogen
Fourier transforms
Stainless steel
Titanium
Infrared radiation
Adsorption
Coatings
Chemical analysis
SUS 316L
baysilon
titanium isopropoxide

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Osaka, A., Yoshioka, T., Yabuta, T., Tsuru, K., & Hayakawa, S. (2005). Blood compatibility of organic-inorganic biomedical materials. Key Engineering Materials, 284-286, 713-716.

Blood compatibility of organic-inorganic biomedical materials. / Osaka, Akiyoshi; Yoshioka, Tomohiko; Yabuta, Takeshi; Tsuru, Kanji; Hayakawa, Satoshi.

In: Key Engineering Materials, Vol. 284-286, 01.12.2005, p. 713-716.

Research output: Contribution to journalArticle

Osaka, A, Yoshioka, T, Yabuta, T, Tsuru, K & Hayakawa, S 2005, 'Blood compatibility of organic-inorganic biomedical materials', Key Engineering Materials, vol. 284-286, pp. 713-716.
Osaka A, Yoshioka T, Yabuta T, Tsuru K, Hayakawa S. Blood compatibility of organic-inorganic biomedical materials. Key Engineering Materials. 2005 Dec 1;284-286:713-716.
Osaka, Akiyoshi ; Yoshioka, Tomohiko ; Yabuta, Takeshi ; Tsuru, Kanji ; Hayakawa, Satoshi. / Blood compatibility of organic-inorganic biomedical materials. In: Key Engineering Materials. 2005 ; Vol. 284-286. pp. 713-716.
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