Blood compatibility of stainless-steel and titanium immobilized with alginic acid layers

Tomohiko Yoshioka, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Contribution to journalConference article

2 Citations (Scopus)

Abstract

γ-Aminopropyltriethoxysilane (γ-APS) was grafted on stainless-steel and titanium substrates, and subsequently alginic acid layer was immobilized on them. Their surfaces were characterized with X-ray photoelectron spectroscopy (XPS) and contact angle measurement. Blood compatibility of thus obtained substrates was evaluated in terms of both the number of the adhered platelets and blood clotting factors for plasma contacted with the substrates such as active partial thromboplastin time (PTT), prothrombin time (PT), and amount of fibrinogen (Fib). The steel and titanium substrates with alginic acid layer did not affect blood clotting factors. In vitro platelet adhesion assay indicated that those substrates adhered less number of platelets than non-treated substrates. Hence the alginic acid immobilization leads to blood compatible surfaces.

Original languageEnglish
Pages (from-to)333-338
Number of pages6
JournalMaterials Research Society Symposium - Proceedings
Volume734
Publication statusPublished - Jun 30 2003
EventPolymer/Metal Interfaces and Defect Mediated Phenomena in Ordered Polymers - Boston, MA, United States
Duration: Dec 2 2002Dec 6 2002

Fingerprint

Alginate
Stainless Steel
Titanium
titanium
Blood
Stainless steel
blood
steel
substrate
acid
Substrates
Platelets
Blood Coagulation Factors
Steel
Thromboplastin
Prothrombin
Angle measurement
adhesion
immobilization
Fibrinogen

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Blood compatibility of stainless-steel and titanium immobilized with alginic acid layers. / Yoshioka, Tomohiko; Tsuru, Kanji; Hayakawa, Satoshi; Osaka, Akiyoshi.

In: Materials Research Society Symposium - Proceedings, Vol. 734, 30.06.2003, p. 333-338.

Research output: Contribution to journalConference article

Yoshioka, Tomohiko ; Tsuru, Kanji ; Hayakawa, Satoshi ; Osaka, Akiyoshi. / Blood compatibility of stainless-steel and titanium immobilized with alginic acid layers. In: Materials Research Society Symposium - Proceedings. 2003 ; Vol. 734. pp. 333-338.
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