Blood concentrations of tetracaine and its metabolite following spinal anesthesia

Keiko Kudo, Yukiko Hino, Noriaki Ikeda, Hidefumi Inoue, Shosuke Takahashi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Blood concentrations of tetracaine and its metabolite, p-butylaminobenzoic acid, were measured after spinal anesthesia with tetracaine which had been administered to patients under going orthopedic surgery. Tetracaine, an ester anesthetic, was given to 10 patients, the dose was 8-14 mg, and blood samples were collected 1, 2 and 6 h after the injection of tetracaine. We used gas chromatography/mass spectrometry for purposes of analysis. Tetracaine was not detected in any blood sample, but the metabolite was detected in each sample with the mean concentrations of 126.5, 97.9 and 43.3 ng/ml at 1, 2 and 6 h, respectively. This data will be useful in determination of the cause of death after spinal anesthesia with tetracaine. (C) 2001 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalForensic Science International
Volume116
Issue number1
DOIs
Publication statusPublished - Feb 1 2001

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Tetracaine
Spinal Anesthesia
Gas Chromatography-Mass Spectrometry
Orthopedics
Anesthetics
Cause of Death
Esters
Injections
Acids

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Blood concentrations of tetracaine and its metabolite following spinal anesthesia. / Kudo, Keiko; Hino, Yukiko; Ikeda, Noriaki; Inoue, Hidefumi; Takahashi, Shosuke.

In: Forensic Science International, Vol. 116, No. 1, 01.02.2001, p. 9-14.

Research output: Contribution to journalArticle

Kudo, Keiko ; Hino, Yukiko ; Ikeda, Noriaki ; Inoue, Hidefumi ; Takahashi, Shosuke. / Blood concentrations of tetracaine and its metabolite following spinal anesthesia. In: Forensic Science International. 2001 ; Vol. 116, No. 1. pp. 9-14.
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