Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

The Fatty Acids and Outcomes Research Consortium (FORCE)

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15–18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20–22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.

Original languageEnglish
Article number2329
JournalNature communications
Volume12
Issue number1
DOIs
Publication statusPublished - Dec 1 2021

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • General
  • Physics and Astronomy(all)

Fingerprint

Dive into the research topics of 'Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies'. Together they form a unique fingerprint.

Cite this