Bone and Men's Health. The role of androgens in bone metabolism

Kenji Ashida, Yuko Akehi, Tadachika Kudo, Toshihiko Yanase

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Testosterone is the major gonadal sex steroid produced by the testis and act as strong androgen. The adrenal glands produce the weaker androgens dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione. These gonadal and adrenal androgens collectively affect skeletal homeostasis in both men and women. Because of the high prevalence of osteoporosis in women, investigators have been concerned especially in estrogen to resolve the mechanisms of bone metabolism. Estrogens play greater role in maintenance of skeletal health than testosterone, the current evidence suggests that androgens also have direct beneficial effects on bone metabolism. Androgens have anti-osteoporotic effect via direct interaction with androgen receptors, as well as effects mediated by estrogen receptors after aromatization to estradiol.

Original languageEnglish
Pages (from-to)165-173
Number of pages9
JournalClinical calcium
Volume20
Issue number2
Publication statusPublished - Jan 1 2010

Fingerprint

Men's Health
Androgens
Bone and Bones
Testosterone
Estrogens
Dehydroepiandrosterone Sulfate
Dehydroepiandrosterone
Androstenedione
Androgen Receptors
Adrenal Glands
Estrogen Receptors
Osteoporosis
Testis
Estradiol
Homeostasis
Steroids
Research Personnel
Health

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ashida, K., Akehi, Y., Kudo, T., & Yanase, T. (2010). Bone and Men's Health. The role of androgens in bone metabolism. Clinical calcium, 20(2), 165-173.

Bone and Men's Health. The role of androgens in bone metabolism. / Ashida, Kenji; Akehi, Yuko; Kudo, Tadachika; Yanase, Toshihiko.

In: Clinical calcium, Vol. 20, No. 2, 01.01.2010, p. 165-173.

Research output: Contribution to journalReview article

Ashida, K, Akehi, Y, Kudo, T & Yanase, T 2010, 'Bone and Men's Health. The role of androgens in bone metabolism', Clinical calcium, vol. 20, no. 2, pp. 165-173.
Ashida K, Akehi Y, Kudo T, Yanase T. Bone and Men's Health. The role of androgens in bone metabolism. Clinical calcium. 2010 Jan 1;20(2):165-173.
Ashida, Kenji ; Akehi, Yuko ; Kudo, Tadachika ; Yanase, Toshihiko. / Bone and Men's Health. The role of androgens in bone metabolism. In: Clinical calcium. 2010 ; Vol. 20, No. 2. pp. 165-173.
@article{e3cc1d29081b4ff4a1925d524d91943f,
title = "Bone and Men's Health. The role of androgens in bone metabolism",
abstract = "Testosterone is the major gonadal sex steroid produced by the testis and act as strong androgen. The adrenal glands produce the weaker androgens dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione. These gonadal and adrenal androgens collectively affect skeletal homeostasis in both men and women. Because of the high prevalence of osteoporosis in women, investigators have been concerned especially in estrogen to resolve the mechanisms of bone metabolism. Estrogens play greater role in maintenance of skeletal health than testosterone, the current evidence suggests that androgens also have direct beneficial effects on bone metabolism. Androgens have anti-osteoporotic effect via direct interaction with androgen receptors, as well as effects mediated by estrogen receptors after aromatization to estradiol.",
author = "Kenji Ashida and Yuko Akehi and Tadachika Kudo and Toshihiko Yanase",
year = "2010",
month = "1",
day = "1",
language = "English",
volume = "20",
pages = "165--173",
journal = "Clinical calcium",
issn = "0917-5857",
publisher = "Iyaku (Medicine & Drug) Journal Co",
number = "2",

}

TY - JOUR

T1 - Bone and Men's Health. The role of androgens in bone metabolism

AU - Ashida, Kenji

AU - Akehi, Yuko

AU - Kudo, Tadachika

AU - Yanase, Toshihiko

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Testosterone is the major gonadal sex steroid produced by the testis and act as strong androgen. The adrenal glands produce the weaker androgens dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione. These gonadal and adrenal androgens collectively affect skeletal homeostasis in both men and women. Because of the high prevalence of osteoporosis in women, investigators have been concerned especially in estrogen to resolve the mechanisms of bone metabolism. Estrogens play greater role in maintenance of skeletal health than testosterone, the current evidence suggests that androgens also have direct beneficial effects on bone metabolism. Androgens have anti-osteoporotic effect via direct interaction with androgen receptors, as well as effects mediated by estrogen receptors after aromatization to estradiol.

AB - Testosterone is the major gonadal sex steroid produced by the testis and act as strong androgen. The adrenal glands produce the weaker androgens dehydroepiandrosterone, dehydroepiandrosterone sulfate, and androstenedione. These gonadal and adrenal androgens collectively affect skeletal homeostasis in both men and women. Because of the high prevalence of osteoporosis in women, investigators have been concerned especially in estrogen to resolve the mechanisms of bone metabolism. Estrogens play greater role in maintenance of skeletal health than testosterone, the current evidence suggests that androgens also have direct beneficial effects on bone metabolism. Androgens have anti-osteoporotic effect via direct interaction with androgen receptors, as well as effects mediated by estrogen receptors after aromatization to estradiol.

UR - http://www.scopus.com/inward/record.url?scp=77950353800&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950353800&partnerID=8YFLogxK

M3 - Review article

C2 - 20118507

AN - SCOPUS:77950353800

VL - 20

SP - 165

EP - 173

JO - Clinical calcium

JF - Clinical calcium

SN - 0917-5857

IS - 2

ER -