Bone augmentation using novel unidirectional porous hydroxyapatite with bone morphogenetic protein-2 on rat skull

Haruhiko Kashiwazaki, Naoki Harada, Toshiyuki Akazawa, Md Arafat Kabir, Yasuhito Minamida, Masaru Murata

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Unidirectional porous hydroxyapatite (UDPHAp) is a material whose microstructure consists of cross- sectional oval pores with a pore diameter in the range of 100-300 m that penetrate through the material. UDPHAp has proven suitable for osteogenesis and angiogenesis. The present study was designed to evaluate the osteogenic effect of a newly developed UDPHAp as a carrier of recombinant human bone morphogenetic protein-2 (rhBMP-2) in a rat onlay graft model. UDPHAp was implanted beneath the calvarial periosteum of rats to simulate alveolar bone augmentation in a clinical condition. At 2 weeks after implantation, UDPHAp with rhBMP-2 resulted in active bone formation, and the augmented bone was connected directly with the original bone, whereas commercialized porous hydroxyapatite (PHAp) with rhBMP-2 showed little bone formation. These results suggest that UDPHAp in this model is suitable for onlay graft and is an effective biomaterial for the rhBMP-2 delivery system.

Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalJournal of Hard Tissue Biology
Volume22
Issue number3
DOIs
Publication statusPublished - Jul 24 2013
Externally publishedYes

Fingerprint

Bone Morphogenetic Protein 2
Durapatite
Hydroxyapatite
Skull
Rats
Bone
Proteins
Bone and Bones
Osteogenesis
Inlays
Grafts
Transplants
Periosteum
Biocompatible Materials
rat Bmp2 protein
Biomaterials
Microstructure
recombinant human bone morphogenetic protein-2

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biochemistry
  • Biomaterials
  • Orthopedics and Sports Medicine
  • Dentistry(all)
  • Cell Biology

Cite this

Bone augmentation using novel unidirectional porous hydroxyapatite with bone morphogenetic protein-2 on rat skull. / Kashiwazaki, Haruhiko; Harada, Naoki; Akazawa, Toshiyuki; Kabir, Md Arafat; Minamida, Yasuhito; Murata, Masaru.

In: Journal of Hard Tissue Biology, Vol. 22, No. 3, 24.07.2013, p. 337-342.

Research output: Contribution to journalArticle

Kashiwazaki, Haruhiko ; Harada, Naoki ; Akazawa, Toshiyuki ; Kabir, Md Arafat ; Minamida, Yasuhito ; Murata, Masaru. / Bone augmentation using novel unidirectional porous hydroxyapatite with bone morphogenetic protein-2 on rat skull. In: Journal of Hard Tissue Biology. 2013 ; Vol. 22, No. 3. pp. 337-342.
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