Bone marrow cell response on carbonate apatite/PCL-coated α-tricalcium phosphate foam

Thi Bang Le, Xing Ling Shi, Ishikawa Kunio, Radzali Othman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The aim of this research work was to investigate in vitro effect of the carbonate apatite/poly(ε- caprolactone) (CO3Ap/PCL) on α-tricalcium phosphate (α-TCP) foam. α-TCP was produced by sintering CaCO3 and CaHPO4•2H2O at 1500°C for 5 h. It was then coated with CO3Ap/PCL (wt/wt=1/3) to improve both mechanical and biological properties. The initial cell attachment and proliferation of the bone marrow cells were carried out on the α-TCP and CO3Ap/PCL-coated α- TCP foams. The cell proliferation was calculated by AlamarBlue assay. The cells were able to migrate and proliferate well on both α-TCP and CO3Ap/PCL-coated α-TCP foams indicating an excellent biocompatibility. The incorporation of CO3Ap on the coating layer improved cellular attachment and accelerated proliferation. Thus, CO3Ap/PCL-coated α-TCP foam might be a promising candidate as implant material.

Original languageEnglish
Title of host publicationFrontiers in Materials and Minerals Engineering
Pages7-12
Number of pages6
DOIs
Publication statusPublished - Jan 8 2014
Event5th Regional Conference on Materials Engineering and the 5th Regional Conference on Natural Resources and Materials 2013, RCM5 and RCNRM5 2013 - , Malaysia
Duration: Jan 22 2013Jan 23 2013

Publication series

NameAdvanced Materials Research
Volume858
ISSN (Print)1022-6680

Other

Other5th Regional Conference on Materials Engineering and the 5th Regional Conference on Natural Resources and Materials 2013, RCM5 and RCNRM5 2013
CountryMalaysia
Period1/22/131/23/13

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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    Le, T. B., Shi, X. L., Kunio, I., & Othman, R. (2014). Bone marrow cell response on carbonate apatite/PCL-coated α-tricalcium phosphate foam. In Frontiers in Materials and Minerals Engineering (pp. 7-12). (Advanced Materials Research; Vol. 858). https://doi.org/10.4028/www.scientific.net/AMR.858.7