TY - JOUR
T1 - Bone marrow fat-cell enlargement in early steroid-induced osteonecrosis - A histomorphometric study of autopsy cases
AU - Motomura, Goro
AU - Yamamoto, Takuaki
AU - Miyanishi, Keita
AU - Yamashita, Akihisa
AU - Sueishi, Katsuo
AU - Iwamoto, Yukihide
N1 - Funding Information:
This work is supported in part by a Research Grant for Intractable Diseases from the Ministry of Health, Labor, and Welfare of Japan, and a Grant-in-Aid in Scientific Research (No. 15591587) from JSPS. We would like to thank Naoko Kinukawa (Department of Medical Informatics, Kyushu University, Fukuoka, Japan) for her helpful advice on the statistical analysis.
PY - 2005/2/22
Y1 - 2005/2/22
N2 - Some animal studies and magnetic resonance imaging studies suggest that there may exist a relationship between abnormal lipid metabolisms and osteonecrosis. The purpose of this study was to examine the size of bone marrow fat cells in the early osteonecrosis femoral head using autopsy specimens. We compared the size of bone marrow fat cells in the viable areas in the following three autopsy groups: the early osteonecrosis group (4 femoral heads); the steroid-administered group (without osteonecrosis) (n = 10), and the normal group (n = 19). In addition, after adjusting for age and sex, the size of bone marrow fat cells was compared using multiple regression analysis. The size of bone marrow fat cells was significantly larger in the early osteonecrosis group (84.7±5.5 μm) than in both the steroid-administered group (75.3±4.3 μm) and the normal group (76.3±4.9 μm) (p < 0.01 and p < 0.05, respectively). After adjusting for age and sex, the size of bone marrow fat cells in the early osteonecrosis group was significantly larger as compared with the other groups. This study suggests that in steroid-induced osteonecrosis, the size of bone marrow fat cells increases significantly at an early stage.
AB - Some animal studies and magnetic resonance imaging studies suggest that there may exist a relationship between abnormal lipid metabolisms and osteonecrosis. The purpose of this study was to examine the size of bone marrow fat cells in the early osteonecrosis femoral head using autopsy specimens. We compared the size of bone marrow fat cells in the viable areas in the following three autopsy groups: the early osteonecrosis group (4 femoral heads); the steroid-administered group (without osteonecrosis) (n = 10), and the normal group (n = 19). In addition, after adjusting for age and sex, the size of bone marrow fat cells was compared using multiple regression analysis. The size of bone marrow fat cells was significantly larger in the early osteonecrosis group (84.7±5.5 μm) than in both the steroid-administered group (75.3±4.3 μm) and the normal group (76.3±4.9 μm) (p < 0.01 and p < 0.05, respectively). After adjusting for age and sex, the size of bone marrow fat cells in the early osteonecrosis group was significantly larger as compared with the other groups. This study suggests that in steroid-induced osteonecrosis, the size of bone marrow fat cells increases significantly at an early stage.
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U2 - 10.1016/j.prp.2004.10.003
DO - 10.1016/j.prp.2004.10.003
M3 - Article
C2 - 15792124
AN - SCOPUS:13544258026
SN - 0344-0338
VL - 200
SP - 807
EP - 811
JO - Pathology Research and Practice
JF - Pathology Research and Practice
IS - 11-12
ER -