Both metabotropic glutamate I and II receptors mediate augmentation of dopamine release from the striatum in methamphetamine-sensitized rats

Takao Shimazoe, Yukiko Doi, Ikumi Arai, Akiko Yoshimatsu, Takako Fukumoto, Shigenori Watanabe

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The role of metabotropic glutamate receptor (mGluR) on dopamine overflow from the striatum was studied in methamphetamine (MAP)-sensitized rats. The increase of dopamine release by MAP was significantly inhibited by perfusion of a mGluR antagonist R,S-α-methyl-4-carboxyphenylglycine. The perfused mGluR agonist 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid enhanced the dopamine level. The enhancement was significantly attenuated by co-perfusion of a mGluR group I antagonist (S)-4-carboxy-3-hydroxyphenylglycine or a mGluR group II antagonist R,S-α-methyl-4-tetrazolylphenylglycine. These suggest that both mGluR group I and II mediate augmentation of dopamine release in MAP-sensitized rats.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalJapanese Journal of Pharmacology
Volume89
Issue number1
DOIs
Publication statusPublished - Jan 1 2002

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Molecular Medicine

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