Abstract
The purpose of this study was to clarify the association of HLA-DRB1 and -DPB1 alleles with multiple sclerosis (MS) in Japanese, to determine whether optico-spinal MS (OS-MS) and conventional MS are immunogenetically distinct, and to verify the role of gender difference in HLA associations of MS. We studied HLA-DRB1 and -DPB1 polymorphisms in 166 Japanese patients with MS. Forty-seven patients were classified as having the optico-spinal MS (OS-MS) and 119 as having conventional MS. A lack of DPB1*0301 and a higher frequency of DPB1*0501 compared with controls (corrected P < 0.0074; odds ratio = 9.48) were found in OS-MS. By contrast, we found for the first time an association of DPB1*0301 with conventional MS in Japanese (corrected P = 0.0444; odds ratio = 3.28). Logistic analysis, adjusted for sex and age, revealed independent associations of DPB1*0301 (P = 0.0004, adjusted odds ratio (aOR) = 4.70), DPB1*0501 (P = 0.0081, aOR = 2.50) and DRB1*1501 (P = 0.0252, aOR = 2.21) with conventional MS. However, the frequencies of DRB1*1501 and DPB1*0501 in male patients with conventional MS were equal to those in male controls while the DPB1*0301 frequency was increased in both male and female patients. We did not find any association of these HLA alleles with disease course and severity. In conclusion, OS-MS is a DPB1*0501-associated distinct subtype of MS, and DPB1*0301 is the most strongly associated allele with conventional MS in Japanese. In addition, gender plays an important role in HLA association with MS.
| Original language | English |
|---|---|
| Pages (from-to) | 199-205 |
| Number of pages | 7 |
| Journal | Tissue antigens |
| Volume | 55 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jan 1 2000 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Biochemistry
- Genetics
Cite this
Both the HLA-DPB1 and -DRB1 alleles correlate with risk for multiple sclerosis in Japanese : Clinical phenotypes and gender as important factors. / Fukazawa, Toshiyuki; Yamasaki, K.; Ito, H.; Kikuchi, S.; Minohara, M.; Horiuchi, I.; Tsukishima, E.; Sasaki, H.; Hamada, T.; Nishimura, Y.; Tashiro, K.; Kira, J.
In: Tissue antigens, Vol. 55, No. 3, 01.01.2000, p. 199-205.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Both the HLA-DPB1 and -DRB1 alleles correlate with risk for multiple sclerosis in Japanese
T2 - Clinical phenotypes and gender as important factors
AU - Fukazawa, Toshiyuki
AU - Yamasaki, K.
AU - Ito, H.
AU - Kikuchi, S.
AU - Minohara, M.
AU - Horiuchi, I.
AU - Tsukishima, E.
AU - Sasaki, H.
AU - Hamada, T.
AU - Nishimura, Y.
AU - Tashiro, K.
AU - Kira, J.
PY - 2000/1/1
Y1 - 2000/1/1
N2 - The purpose of this study was to clarify the association of HLA-DRB1 and -DPB1 alleles with multiple sclerosis (MS) in Japanese, to determine whether optico-spinal MS (OS-MS) and conventional MS are immunogenetically distinct, and to verify the role of gender difference in HLA associations of MS. We studied HLA-DRB1 and -DPB1 polymorphisms in 166 Japanese patients with MS. Forty-seven patients were classified as having the optico-spinal MS (OS-MS) and 119 as having conventional MS. A lack of DPB1*0301 and a higher frequency of DPB1*0501 compared with controls (corrected P < 0.0074; odds ratio = 9.48) were found in OS-MS. By contrast, we found for the first time an association of DPB1*0301 with conventional MS in Japanese (corrected P = 0.0444; odds ratio = 3.28). Logistic analysis, adjusted for sex and age, revealed independent associations of DPB1*0301 (P = 0.0004, adjusted odds ratio (aOR) = 4.70), DPB1*0501 (P = 0.0081, aOR = 2.50) and DRB1*1501 (P = 0.0252, aOR = 2.21) with conventional MS. However, the frequencies of DRB1*1501 and DPB1*0501 in male patients with conventional MS were equal to those in male controls while the DPB1*0301 frequency was increased in both male and female patients. We did not find any association of these HLA alleles with disease course and severity. In conclusion, OS-MS is a DPB1*0501-associated distinct subtype of MS, and DPB1*0301 is the most strongly associated allele with conventional MS in Japanese. In addition, gender plays an important role in HLA association with MS.
AB - The purpose of this study was to clarify the association of HLA-DRB1 and -DPB1 alleles with multiple sclerosis (MS) in Japanese, to determine whether optico-spinal MS (OS-MS) and conventional MS are immunogenetically distinct, and to verify the role of gender difference in HLA associations of MS. We studied HLA-DRB1 and -DPB1 polymorphisms in 166 Japanese patients with MS. Forty-seven patients were classified as having the optico-spinal MS (OS-MS) and 119 as having conventional MS. A lack of DPB1*0301 and a higher frequency of DPB1*0501 compared with controls (corrected P < 0.0074; odds ratio = 9.48) were found in OS-MS. By contrast, we found for the first time an association of DPB1*0301 with conventional MS in Japanese (corrected P = 0.0444; odds ratio = 3.28). Logistic analysis, adjusted for sex and age, revealed independent associations of DPB1*0301 (P = 0.0004, adjusted odds ratio (aOR) = 4.70), DPB1*0501 (P = 0.0081, aOR = 2.50) and DRB1*1501 (P = 0.0252, aOR = 2.21) with conventional MS. However, the frequencies of DRB1*1501 and DPB1*0501 in male patients with conventional MS were equal to those in male controls while the DPB1*0301 frequency was increased in both male and female patients. We did not find any association of these HLA alleles with disease course and severity. In conclusion, OS-MS is a DPB1*0501-associated distinct subtype of MS, and DPB1*0301 is the most strongly associated allele with conventional MS in Japanese. In addition, gender plays an important role in HLA association with MS.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034149934&partnerID=8YFLogxK
U2 - 10.1034/j.1399-0039.2000.550302.x
DO - 10.1034/j.1399-0039.2000.550302.x
M3 - Article
C2 - 10777094
AN - SCOPUS:0034149934
VL - 55
SP - 199
EP - 205
JO - HLA
JF - HLA
SN - 2059-2302
IS - 3
ER -